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Toxicities and Side Effects Flashcards

1
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: Acetaminophen

A

Rx: N-acetylcysteine (replenishes glutathione)

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2
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: Salicylates

A

Rx: NaHCO3 (alkalinize urine), dialysis

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3
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: Amphetamines (basic)

A

Rx: NH4Cl (acidify urine)

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4
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: AchE inhibitors, organophosphates

A

Rx: Atropine, Pralidoxime

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5
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: Antimuscarinic, anticholinergic agents

A

Rx: Physostigmine salicylate, control hyperthermia

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6
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: B-blockers

A

Rx: Glucagon

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7
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: Digitalis

A

Rx: Normalize K+, Lidocaine, Anti-dig Fab fragments, Mg2+

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8
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: Iron

A

Rx: Deferoxamine, deferasirox

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9
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: Lead

A

Rx: CaEDTA, dimercaprol, succimer, penicillamine

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10
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

tox: Mercury, arsenic, gold

A

Rx: Dimercaprol (BAL), succimer

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11
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: Copper, arsenic, gold

A

Rx: Penicillamine

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12
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: Cyanide

A

Rx: Nitrite + thiosulfate, hydroxocobalamin

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13
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: Methemoglobin

A

Rx: Methylene blue, vit C

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14
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: CO

A

Rx: 100% O2, Hyperbaric O2

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15
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: Methanol, ethylene glycol (antifreeze)

A

Rx: Fomepizole> ethanol, dialysis

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16
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: Opiods

A

Rx: Naloxone/naltrexone

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17
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: Benzodiazepines

A

Rx: Flumazenil

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18
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: TCAs

A

Rx: NaHCO3 (plasma alkalinization)

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19
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: Heparin

A

Rx: Protamine

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20
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: Warfarin

A

Rx: Vit K, FFP

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21
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: tPA, Streptokinase, Urokinase

A

Rx: Aminocaproic acid

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22
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tox: Theophylline

A

Rx: B-blocker

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23
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Rxn: Coronary vasospasm

A

Rx: Cocaine, sumatriptan, ergot alkaloids

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24
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Rxn: Cutaneous flushing

A

Rx: Vancomycin, Adenosine, Niacine, Ca2+ channel, blockers

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25
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Dilated cardiomyopathy
Rx: Doxorubicin (Adriamycin), daunorubicin
26
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Torsades de pointes
Rx: Class III (Sotalol) and class IA (quinidine) anti-arrhyth
27
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Agranulocytosis
Rx: Clozapine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole, Dapsone
28
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Aplastic anemia
Rx: Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole
29
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Direct Coombs + hemolytic anemia
Rx: Methyldopa, PCN
30
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Gray baby syndrome
Rx: Chloramphenicol
31
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Hemolysis in G6PD-defic pts
Rx: Isoniazid (INH), Sulfonamides, Primaquine, ASA, Ibuprof, Nitrofurantoin
32
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Megaloblastic anemias
Rx: Phenytoin, Methotrexate, Sulfa drgs
33
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Thrombotic complications
Rx: OCPs (estrogens)
34
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Cough
Rx: ACE-i
35
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Pulm fibrosis
Rx: Bleomycin, Amiodarone, Busulfan
36
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Acute cholestatic hepatitis, jaundice
Rx: Erythromycin
37
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Focal-massive hepatic necrosis
Rx: Halothane, Amanita phalloides, Valproic acid, Acetaminophen
38
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Hepatitis
Rx: INH
39
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Pseudomembranous colitis
Rx: Clindamycin, ampicillin
40
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Adrenocortical insuffic
Rx: Glucocorticoid w/drawal (HPA suppression)
41
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Gynecomastia
Rx: Spironolactone, Digitalis, Cimeditine, chronic alcohol use, estrogens, Ketoconazole
42
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Hot flashes
Rx: Tamoxifen, Clomiphene
43
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Hyperglycemia
Rx: Niacin, tacrolimus, protease-i, HCTZ, corticosteroids
44
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Hypothyroidism
Rx: Lithium, Amiodarone, Sulfonamides
45
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Fat redistribution
Rx: Glucocorticoids, protease-i
46
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Gingival hyperplasia
Rx: Phenytoin, Verapamil
47
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Gout
Rx: Furosemide, Thiazides, NIacin, Cyclosporine
48
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Myopathies
Rx: Fibrates, Niacin, Colchicine, Hydroxychloroquine, Interferon-a, Penicillamine, Statins, Glucocorticoids
49
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Osteoporosis
Rx: Corticosteroids, heparin
50
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Photosensitivity
Rx: Sulfonamides, Amiodarone, Tetracycline
51
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Rash (SJS)
Rx: PCN, Ethosuximide, Carbamazepine, Sulfa drugs, Lamotrigine, Allopurinol, Phenytoin, Phenobarbital
52
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: SLE-like syndrome
Rx: Hydralazine, INH, Procainamide, Phenytoin
53
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Teeth changes (kds)
Rx: Tetracyclines
54
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Tendonitis, tendon rupture, cartilage dmge
Rx: Fluoroquinolones
55
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: DI
Rx: Lithium, demeclocycline
56
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Fanconi's
Rx: Expired tetraycline
57
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Hemorrhagic cystitis
Rx: Cyclophosphamide, Ifosfamide (prevent by coadministering with mesna)
58
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Interstitial nephritis
Rx: Methicillin, NSAIDs, furosemide
59
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: SIADH
Rx: Carbamazepine, cyclophosphamide
60
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Cichoism
Rx: Quinidine, Quinine
61
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Parkinson-like syndrome
Rx: Antipsychotics, Reserpine, Metoclopramide
62
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Seizures
Rx: Isoniazid, Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide
63
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Tardive dyskinesia
Rx: Antipsychotics
64
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Antimuscarinic
Rx: Atropine, TCAs, H1-blockers, Neuroleptics
65
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Disulfiram-like rxn
Rx: Metronidazole, certain Cephalosporins, Procarbazine, 1st-gen Sulfonylureas
66
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Nephrotoxicity/Ototoxicity
Rx: Aminoglycosides, Vancomycin, Loop diuretics, Cisplatin
67
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rxn: Serotonin Syndrome
Rx: Cryoheptadine (5-HT1/2 receptor antagonist, Antihistamine)
68
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note P-450 Inducers
``` Modafinil Barbiturates St. John's wort Phenytoin Rifampin Griseofulvin Carbamazepine Chronic alcohol use ```
69
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note P-450 Inhibitors
``` Macrolides Amiodarone Grapefruit juice Isoniazid Cimetidine Ritonavir Acute alcohol abuse Ciprofloxacin Ketoconazole Sulfonamides Gemfibrozil Quinidine ```
70
# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Sulfa drugs
Probenicid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonamide Ab's, Sulfasalazine, Sulfonylureas -Rxns: fever, UTI, pruritic rash, SJS, hemolytic anemia, thrombocytopenia, agranulocytosis, and urticaria (hives)

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