Heme/Onc Rx

Question 1

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Mineral/Vitamin: Ferrous Sulfate

Answer 1

1) Use: Iron defiecnt anemia
2) Class/MOA:
3) Side effects/ADEs: Constipation
4) Fun Facts

Question 2

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Mineral/Vitamin: Iron dextran = Iron sucrose

Answer 2

1) Use: FE Deficency Anemia
2) Class/MOA:
3) Side effects/ADEs: anaphalazis
4) Fun Facts

Question 3

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Mineral/Vitamin: Folic Acid

Answer 3

1) Use: PND, traumatic cardiac hemolytic anemia, folate defiency (alcoholism)
2) Class/MOA:
3) Side effects/ADEs:
4) Fun Facts

Question 4

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Mineral/Vitamin: Vitamin B12

Answer 4

1) Use: Pernicious Anemia
2) Class/MOA:
3) Side effects/ADEs:
4) Fun Facts

Question 5

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Desferrioxamine (Deferoozamine or Desferal)

Answer 5

1) Use: Thalasemias, or other disease with regular blood transfusions - helps avoid iron overload (causes cirrhosis, CHF, DM)
2) Class/MOA: IRON CHELATOR (NOT ORAL!)
3) Side effects/ADEs:
4) Fun Facts

Question 6

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Deferasirox (EXJADE)

Answer 6

1) Use: Thalasemias, or other disease with regular blood transfusions - helps avoid iron overload (causes cirrhosis, CHF, DM)
2) Class/MOA: Iron Cheltors ORAL
3) Side effects/ADEs:
4) Fun Facts

Question 7

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Epoeitin

Answer 7

1) Use: anemia
2) Class/MOA: GROWTH FACTOR EPO = increases RBC
3) Side effects/ADEs:
4) Fun Facts

Question 8

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Filgrastim (G-CSF; Neupogen); Sargramostim (GM-CSF; Leukine); Peg-Filgrastim (Neulasta)

Answer 8

1) Use: GROWTH FACTOR any chemo that causes neutropenia; meylosuppressive therapy
2) Class/MOA: stimulates proliferation, matruation and efficacy of NEUTROPHILS via JAK/STAT tyrosine kinase pathway
3) Side effects/ADEs:
4) Fun Facts: same as G-CSF

Question 9

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

IL-11 (Oprelvekin, Neumega) Rx: thrombocytopenia

Answer 9

1) Use: GROWTH FACTOR thrombocytopenia
2) Class/MOA: stimulates the growth of primative MEGAKARYOCYTE progenitors - increase megakaryocytes, increase peripheral platelets
3) Side effects/ADEs: fatigue, headache, CVE
4) Fun Facts:

Question 10

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Growth Factor: Romiplostim (Nplade) - Thrombopoeitin analog - Rx for chronic ITP

Answer 10

1) Use: GROWTH FACTOR thrombocytopenia
2) Class/MOA: same as IL-12: stimulates growth of primative megakarycytic progenitors, increasing megakaryocytes, increasing platelets
3) Side effects/ADEs: fatigue, headache, CVE
4) Fun Facts

Question 11

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Asprinin

Answer 11

1) Use: PLATELET INHIBITOR
2) Class/MOA: Actylates and irreversibly inhibits COX-1 and COX-2 to prevent conversion of arachadonic acid to thromboxane A2
3) Side effects/ADEs: increase BT, no effect on PT, PTT | Gastric ulcertation, bleeding, hyperventilation, Reye’s Syndr

Question 12

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Ticlopidine, Clopidogrel (Plavix)

Answer 12

1) Use: PLATELET INHIBITOR
2) Class/MOA: Inhibit platelet aggregation by irreversibly blocking ADP RECEPTORS | inhibit fibrinogen binding by preventing glycoprotein Iib/I

Question 13

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Abciximab (Rheopro), Eptidibatide (Integrilin) and Tirofibiban (Aggrastat)

Answer 13

1) Use: PLATELET INHIBITOR
2) Class/MOA: Monoclonal antibody that binds to the GLYCOPROTEIN RECEPTOR Ib/IIIa on activated platelets, preventing aggregation
3) Side effects/ADEs: bleeding, thrombocytop

Question 14

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Dipyridamole

Answer 14

1) Use: PLATELET INHIBITOR
2) Class/MOA: increase cAMP = decrease ADENOSINE uptake/cyclic nucleotide PDE = decreased aggregation
3) Side effects/ADEs: serious bleeding risk
4) Fun Facts

Question 15

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Heparin

Answer 15

1) Use: immediate ANTICOAG for PE, stroke, ACS, MI, DVT | used during pregnancy | follow PTT
2) Class/MOA: INHIBITS THROMBIN ACTION | cofactor for activation of ANTI-THROMBIN, decrease thrombin and Xa, short 1/2 life
3) Side effects/ADEs: Bleeding, thrombocytopenai (HIT),

Question 16

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Enoxaparin (LMWH, Lovenox)

Answer 16

1) Use: Anticoagulation
2) Class/MOA: Cofactor for activation of ANTITHROMBIN and Xa (work better on Xa), better bioavailibilty and 2-4 times longer 1/2 life - can be administered subQ and without lab monitoring
3) Side effects/ADEs: can’t reverse esily

Question 17

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Lepirudin, Bilirudin

Answer 17

1) Use:
2) Class/MOA: Hirudin derivatives; directly INHIBITS THROMBIN
3) Side effects/ADEs:
4) Fun Facts: used as an alternative to heparin for anticoagulating patients with HIT

Question 18

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Argatroban

Answer 18

1) Use: HIT, patient with kidney dysfunction
2) Class/MOA: directly INHIBITS THROMBIN
3) Side effects/ADEs: falsely elevates INR levels
4) Fun Facts: irreversible

Question 19

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Warfarin

Answer 19

1) Use: Chronic anticoagulation | not used in pregnat women | follow PT/INR values
2) Class/MOA: interfears with normal synthesis of K depedent clotting factors through blocking | INHIBIT THROMBIN GENERATION
3) Side effects/ADEs: bleeding, teratogenic,

Question 20

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Alteplase (tPA)

Answer 20

1) Use: CVA, acute MI, PE
2) Class/MOA: converts plasminogen to plasmin and helps cleave fibrin mesh TPA
3) Side effects/ADEs: bleeding
4) Fun Facts

Question 21

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Protamine Sulfate

Answer 21

1) Use: REVERSES HEPRIN
2) Class/MOA:
3) Side effects/ADEs:
4) Fun Facts

Question 22

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

DDAVP (Desmopressin)

Answer 22

1) Use: vWF disease
2) Class/MOA: RELEASES vWF stored in endothelium
3) Side effects/ADEs:
4) Fun Facts

Question 23

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Vitamin K

Answer 23

1) Use: REVERSES Warfarin
2) Class/MOA:
3) Side effects/ADEs:
4) Fun Facts

Question 24

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Novo VII

Answer 24

1) Use: potent means to stop bleeding!
2) Class/MOA: BASICALLY FACTOR VII | binds activated platelets and catalysex X-> Xa, which turns activated factor II -> Iia (thrombin)
3) Side effects/ADEs: thrombosis
4) Fun Facts

Question 25

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Aminocaproid Acid (AMICAR)

Answer 25

TREATMENT OF BLEEDING all anti fibrinolytic - a drug to stop a clot from breaking down

Question 26

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Cyclophoasphamide, Ifosphasmide

Answer 26

1) Use: NHL, breast/ovarian carcinomas | immunosupressant 2) Class/MOA: ANTINEOPLASTIC AGENT | ALKYLATING AGENT | Covalently links X-link (intrastrand) DNA at guanine N-7 | requires bioactivation by the liver 3) Side effects/ADEs: Myelosupression, hemor

Question 27

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Busulfan

Answer 27

1) Use: CML - ablate bone marrow before BM transplant 2) Class/MOA: ANTINEOPLASTIC AGENT | ALYKATING AGENT | lkylates DNA 3) Side effects/ADEs: Pulmonary fibrosis, hyperpigmentation 4) Fun Facts

Question 28

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Bendamustine

Answer 28

1) Use: Refractory CLL, low NHL 2) Class/MOA: ANTINEOPLASTIC AGENT | Alkylating agent - Nitrogen Mustard 3) Side effects/ADEs: NO allopecia, liver irritation, fatigue, rash 4) Fun Facts

Question 29

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Nitrosoureas (BCNU - Carmustine) & (CCNU - Lomustine)

Answer 29

1) Use: Brain tumors (including glioblastoma multifome) 2) Class/MOA: ANTINEOPLASTIC AGENT | ALKYLATING AGENT | Require bioactivation | cross BBB = CNS 3) Side effects/ADEs: CNS tocicity (dizziness, ataxia) 4) Fun Facts

Question 30

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Cisplatin (& mesna), Carboplatin

Answer 30

1) Use: Testicular, bladder, ovary and lung carcinomas 2) Class/MOA: ANTINEOPLASTIC AGENT | ALKYLATING AGENT | Cross-link DNA 3) Side effects/ADEs: Nephrotoxicity and acoustic nerve damage 4) Fun Facts

Question 31

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Methotrexate - Leucivorin (Folinic Acid)

Answer 31

1) Use: Cancers (leukemias, lymphomas, choriocarcinoma, sarcoma) non-neoplastics (abortion, ectopic pregancy, RA, psoriasis) 2) Class/MOA: ANTINEOPLASTIC AGENT | ANTIMETABOLITE | FOLIC ACID ANALOG that inhibits dihydroredutase = decrease in dTMP = decrea

Question 32

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note 6-mercaptopurine and 6-thioguanine

Answer 32

1) Use: Leukemias, lymphomas (not CLL or HD) 2) Class/MOA: ANTINEOPLASTIC AGENT | ANTIMETABOLITE | PURINE ANALOG | Purine analog = decreased de novo purine syntehsis | activated by HGPRTas 3) Side effects/ADEs: BM, GI, Liver | metabolized by xanthene ox

Question 33

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note 5-Flurouracil

Answer 33

1) Use: Colon cancer and other solid tumors, basal cell carcinoma (topical), synergy with MTX 2) Class/MOA: ANTINEOPLASTIC AGENT | ANTIMETABOLITE | PYRIMIDINE ANALOG | bioactivated to 5F-dUMP, which covalently complexes folic acid | this complex inhibits

Question 34

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note 5-azacitidine

Answer 34

1) Use: MDS 2) Class/MOA: ANTINEOPLASTIC AGENT | ANTIMETABOLITE | PYRIMIDINE ANALOG, also restore function of tumor supressor gene 3) Side effects/ADEs: 4) Fun Facts

Question 35

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Cytarabine (Ara-C)

Answer 35

1) Use: AML, ALL, high grade non-Hodgkin's lymphoma 2) Class/MOA: ANTINEOPLASTIC AGENT | ANTIMETABOLITE | PYRIMIDINE ANTAGONIST inhibition of DNA polymerase 3) Side effects/ADEs: Leukopenia, thrombocytopenia, megaloblastic anemia 4) Fun Facts

Question 36

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Dactinomycin (Antinomycin D)

Answer 36

1) Use: Wilms tumor, Ewig's sarcoma, rahbdo, childhood tumors (kids ACT out!) 2) Class/MOA: ANTINEOPLASTIC AGENT | NATURAL PRODUCT | Intercalates in DNA 3) Side effects/ADEs: Myelosupression 4) Fun Facts

Question 37

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Doxorubicin (Adriamycin), Daunorubicin

Answer 37

1) Use: HD, myelomas, sarcomas and solid tumors 2) Class/MOA: ANTINEOPLASTIC AGENT | NATURAL PRODUCT | Generates free radicles | noncovalently intercalates in DNA = BREAKS IN DNA = decreased replicatoin 3) Side effects/ADEs: cardiotoxicity; myelosupress

Question 38

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Bleomycin

Answer 38

1) Use: Testicular cancer, HD 2) Class/MOA: ANTINEOPLASTIC AGENT | NATURAL AGENT | Induces free radical formation; which causes BREAKS IN DNA strands 3) Side effects/ADEs: Pulomonary firbosis, skin changes, minimal myelosupression 4) Fun Facts

Question 39

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Vincristine, Vinblastine

Answer 39

1) Use: HD, Wilms, Choriocarcinoma 2) Class/MOA: ANTINEOPLASTIC AGENT | NATURAL PRODUCT | Alkaloids that BIND TO TUBULIN in M-phase and block polyermization of MICROTUBULES so that mitotic spindle can't form 3) Side effects/ADEs: neurotoxicity | Blast's

Question 40

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Etoposide

Answer 40

1) Use: Small Cell Cardinoma of the lung and prostate, testicular Carcinoma 2) Class/MOA: ANTINEOPLASTIC AGENT: NATURAL PRODUCT: Inhibits TOPOisomerase II = increase in DNA degradation 3) Side effects/ADEs: myelosupression, GI irritation, alopecia 4) F

Question 41

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Paclitaxel

Answer 41

1) Use: Ovarian and breast carcinomas 2) Class/MOA: ANTINEOPLASTIC AGENT | NATURAL PRODUCT hyperstablizes polymerized microtubules in M phase so that MITOTIC SPINDLE spindle can't break down (anaphase can't occur) 3) Side effects/ADEs: myelosuppresion

Question 42

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Hydroxurea

Answer 42

1) Use: Melanoma, CML, sickle cell 2) Class/MOA: ANTINEOPLASTIC AGENT Inhibits RIBONUCULOTIDE REDUCTASE = decrease in DNA synthesis 3) Side effects/ADEs: BM supression, GI upset 4) Fun Facts

Question 43

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Thalidomide and Lenolidamide

Answer 43

1) Use: MM 2) Class/MOA: ANTINEOPLASTIC AGENT | SUPRESS ANGIONEOGENESIS, immunomodulate, pro-apoptottic? 3) Side effects/ADEs: Birth defects 4) Fun Facts

Question 44

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Tamoxifin, Raloxifene

Answer 44

1) Use: Breast cancer & osteoporosis 2) Class/MOA: SERM - receptor antagonists in the breast, and antagonist in bone | block the binding of estogren to estrogen receptor positive cells 3) Side effects/ADEs: T: increase risk of endometrial carcinoma via

Question 45

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Anastrolzole

Answer 45

1) Use: postmenopausal women with breast cancer 2) Class/MOA: ANTINEOPLASTIC AGENT: HORMONES : AROMATASE INHIBITOR 3) Side effects/ADEs: 4) Fun Facts

Question 46

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Flutamide

Answer 46

1) Use: prostate carcinoma 2) Class/MOA: ANTINEOPLASTIC AGENT: HORMONES a nonsteroidal competitive inhibitor of androgens at the testosterone inhibitor 3) Side effects/ADEs: 4) Fun Facts

Question 47

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Fulvestrant

Answer 47

1) Use: advanced breast cancer 2) Class/MOA: ANTINEOPLASTIC AGENT | HORMONES | binds E receptor, accelerates destruction 3) Side effects/ADEs: E withdrawl, muscle wasting and gynecomastia 4) Fun Facts

Question 48

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Leuprolide

Answer 48

1) Use: Infertility, prostate cancer, uterine fibrosis 2) Class/MOA: ANTINEOPLASTIC AGENT: HORMONE: GnRH analog with agonist properties when used in pulsatile fasion; antagonist properties wihen used in continous fashion 3) Side effects/ADEs: antiandrog

Question 49

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Ketoconazole

Answer 49

1) Use: PCOS to prevent hirtuism, 2) Class/MOA: ANTINEOPLASTIC AGENT: HORMONE inhibits STEROID syntehsis (inhibits desmolase) 3) Side effects/ADEs: Gynecomastia and amenorrhea 4) Fun Facts

Question 50

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Rituximab (Rituxan)

Answer 50

1) Use: NHL, RA (with MTX) 2) Class/MOA: ANTINEOPLASTIC AGENT: MONOCLONAL ANTIBODY TO CD-20, which is found on most B-cell neoplasms 3) Side effects/ADEs: 4) Fun Facts

Question 51

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Ibritumomab Tiuxetan (Zevalin)

Answer 51

1) Use: HD 2) Class/MOA: ANTINEOPLASTIC AGENT | MONOCLONAL ANTIBODY 3) Side effects/ADEs: infusion reactions 4) Fun Facts

Question 52

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Gemtuzumab Ogozamiin (Mylotarg)

Answer 52

Anti-CD33

Question 53

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Trastuxumab (Herceptin)

Answer 53

1) Use: Metastatic breast cancer 2) Class/MOA: monoclonal Ab against HER-2 (erb-B2) helps kill breast cancer cells that overexpress HER-2, possibly through antibody dependent cytotoxicity 3) Side effects/ADEs: Cardiotoxicity 4) Fun Facts

Question 54

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Cetuzimab (Erbitux)

Answer 54

1) Use: Metestatic Breast Cancer 2) Class/MOA: ANTINEOPLASTIC AGENT MONOCLONAL ANTIBODY TO HER-2 (erb-B2) | helps kill breast cancer cells that overexpress HER-2 possibly through antibody-dependent cytotoxicity 3) Side effects/ADEs: cardiotoxicity 4) F

Question 55

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Bevacizumab (Avastin)

Answer 55

1) Use: Mets lung, colon, breast, renal cell, glioblastoma 2) Class/MOA: ANTINEOPLASTIC AGENT radioimmunotherapy, binds VEGF & prevents interaction with its R - decreased endothelial cell prolifeation and decreased new blood vessel formation 3) Side e

Question 56

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Erlotinib (Tarceva)

Answer 56

1) Use: 2) Class/MOA: ANTINEOPLASTIC AGENT small molecule, inhibits EGFR - TK1 inhibitor, preents posphorylation, prevents phosphorylation of tyrosine kinase 3) Side effects/ADEs: Skin rash, fatigue, Diarrhea $$$ 4) Fun Facts

Question 57

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Bortexomib (Velcade)

Answer 57

1) Use: MM 2) Class/MOA: ANTINEOPLASTIC AGENT Small molecule, PROTEASE inhibitor - decrased NFKB activation (cells explode because they ant breakdown proteins they contain 3) Side effects/ADEs: Neruropathy, htormbocytopenia, fever, diarrhea, $$$$ 4) Fun

Question 58

# 1) uses 2) class/ MOA 3) ADE 4)Fun fact/note Imatinib (Gleevec)

Answer 58

1) Use: CML, GI stromal tumors 2) Class/MOA: ANTINEOPLASTIC AGENT PHILDELPHIA CHRphilidelphia chromosome bcr-abl tyrosine kinase inhibitor 3) Side effects/ADEs: fluid retention 4) Fun Facts