Autonomic Sympathetic Drugs: Indirect Sympathomimetics

Question 1

catecholamines

Answer 1

epinephrine, norepinephrine, dopamine

Question 2

adrenergic nerve terminal is the site of action of

Answer 2

indirect sympathomimetics

Question 3

Site of action of indirect sympathomimetics

Answer 3

adrenergic nerve terminal

Question 4

tyrosine is transported to

Answer 4

the vesicle containing neurotransmitters in the presynaptic nerve terminal

Question 5

Which amino acid is a precursor to catecholamines

Answer 5

tyrosine

Question 6

Tyrosine is converted to

Answer 6

L-DOPA

Question 7

L-DOPA is converted to

Answer 7

dopamine

Question 8

metyrosine prevents

Answer 8

conversion of tyrosine to L-DOPA

Question 9

metyrosine is a

Answer 9

tyrosine analog

Question 10

dopamine is converted to norepinephrine in the

Answer 10

vesicle containing neurotransmitters in the presynaptic neuron

Question 11

norepinephrine transporter (NET)

Answer 11

norepinephrine transporter (NET) transports norepinephrine (and dopamine) back into the presynaptic neuron

Question 12

dopamine transporter (DAT)

Answer 12

dopamine transporter (DAT) transports dopamine back to the presynaptic neuron

Question 13

cocaine inhibits

Answer 13

cocaine inhibits

Question 14

cocaine can cause

Answer 14

1. agitation
2. pupillary dilation
3. hypertension
4. tachycardia
5. nasal mucosal atrophy or septal perforation
6. coronary vasospasm and myocardial ischemia

Question 15

cocaine can cause nasal mucosal atrophy or septal perforation due to

Answer 15

vasoconstriction

Question 16

cocaine induced coronary vasospasm can cause

Answer 16

angina

Question 17

in cocaine intoxication beta-blockers can cause

Answer 17

beta-blockers can cause severe hypertension in cocaine intoxication (unopposed alpha-1 stimulation)

Question 18

NET inhibitor

Answer 18

atomoxetine

Question 19

atomoxetine treats

Answer 19

attention deficit and hyperactivity disorder (ADHD)

Question 20

________ are transported by vesicular monoamine transporter (VMAT)

Answer 20

catecholamines

Question 21

catecholamines are transported by VMAT into

Answer 21

presynaptic vesicle

Question 22

Reserpine

Answer 22

reserpine inhibits VMAT, depleting neurotransmitter stores

Question 23

Amphetamines

Answer 23

displace catecholamines (norepinephrine, dopamine) into synapse

Question 24

amphetamines can be used to treat

Answer 24

ADHD

Question 25

methylphenidate is an

Answer 25

is an amphetamine derivative

Question 26

methylphenidate treats

Answer 26

ADHD

Question 27

Treats ADHD

Answer 27

1. methylphenidate 2 amphetamine 3. atomoxetine

Question 28

Modafinil is a

Answer 28

stimulant used to treat narcolepsy

Question 29

Stimulants include

Answer 29

1. amphetamines 2. methylphenidate 3. modafinil

Question 30

Stimulants suppress

Answer 30

appetite

Question 31

D1 is coupled to

Answer 31

Gs

Question 32

D2 is coupled to

Answer 32

Gi

Question 33

low doses of dopamine act on D1 receptors to

Answer 33

increases renal blood flow

Question 34

medium doses of dopamine activate

Answer 34

beta-1 receptors (cardiac activation)

Question 35

high doses of dopamine activate

Answer 35

alpha-1 receptors (pressor effects)

Question 36

D2 receptors are found in the

Answer 36

CNS