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Sketchy Medical > Dyslipidemia Drugs: Fibrates and Niacin > Flashcards

Dyslipidemia Drugs: Fibrates and Niacin Flashcards

1
Q

Triglycerides in VLDLs are hydrolyzed by

A

LPL

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2
Q

Triglycerides in VLDLs are hydrolyzed by LPL releasing

A

free fatty acids

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3
Q

Free fatty acids can be used for

A

energy by heart and skeletal muscle

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4
Q

Free fatty acids can be converted back into

A

triglycerides and stored in adipose tissue

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5
Q

Fibrates are

A
  1. Gemfibrozil

2. Fenofibrate

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6
Q

Fibrates activate

A

PPAR-alpha

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7
Q

Fibrates activate PPAR-alpha to

A

upregulate LPL

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8
Q

Fibrates decrease

A
  1. Serum triglycerides
  2. Serum VLDL
  3. Serum LDL
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9
Q

Fibrates decrease serum VLDL

A

35-50% by stimulating LPL and reduced hepatic VLDL secretion

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10
Q

Fibrates decrease serum triglycerides

A

increase hydrolysis of VLDL and chylomicron triglycerides via LPL

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11
Q

Fibrates decrease serum LDL by

A

reducing VLDL

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12
Q

Fibrates have a mild effect on ______

A
  1. LDL

2. HDL

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13
Q

Fibrates increase serum

A

HDL

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14
Q

Fibrates combined with statins increases risk of

A

myopathy

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15
Q

Fibrates side effects

A

Cholesterol Gall Stones

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16
Q

Niacin is also known as

A

Vitamin B3

17
Q

Niacin is the most effective drug for

A

increasing serum HDL (~30%)

18
Q

What is the most effective drug for increasing serum HDL

A

niacin

19
Q

Niacin decreases serum

A
  1. Triglycerides
  2. VLDL
  3. LDL
20
Q

Niacin decreases serum triglycerides

A

reduces hepatic VLDL secretion

21
Q

Niacin decreases serum VLDL

A

reduces hepatic VLDL secretion

22
Q

Niacin decreases serum LDL by

A

lowering VLDL

23
Q

Niacin has a mild effect on

A

LDL

24
Q

Niacin side effects

A
  1. Cutaneous flushing and warmth
  2. Hyperglycemia
  3. Hyperuricemia and precipitate gout
  4. elevated liver function tests (LFTs) leading to severe hepatotoxicity (requires monitoring)
25
Q

Why does Niacin cause flushing

A

Prostaglandins

26
Q

_______ can be used to prevent flushing from niacin

A

NSAIDs (including aspirin)

27
Q

Fish oils are

A

omega-3-fatty acids

28
Q

Fish oil can

A

lower serum triglycerides (by decreasing VLDL and apoB production)

Sketchy Medical (46 decks)

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