Flashcards in B2.081 Prework 1 The Fluid Mosaic Model Deck (21)
what are the 6 properties of membranes?
1.components: lipids and proteins
3. noncovalent assembly
what are the two classes of phospholipids?
derivatives of glycerol or sphingosine
what are the components of a glycerol derived phospholipid?
2 fatty acid tails
saturated vs. unsaturated fatty acids
saturated = single bonds, staggered
unsaturated = double bonds, kinked at double bond locations
what do alcohols attached to phosphatidate have in common?
charged, polar, or aromatic
what is a phosphatidate
phospholipid without alcohol group
what are the components of a sphingosine derived phospholipid?
what is the simplest glycolipid?
what are gangliosides?
sphingosine lipids with many sugar residues
what happens to amphipathic lipids in water
they assemble into noncovalent structures
what is the function of cholesterol?
modulates membrane flexibility/fluidity
what are the types of membrane proteins?
how are protein islands formed?
integral proteins shift laterally due to binding of signaling proteins
how does the membrane mediate cell shape changes?
membrane proteins interact with the cytoskeleton forming a mesh pattern
what are cytoskeleton corrals?
limits where membrane proteins can travel by preventing lateral motions
what are some sources of membrane asymmetry?
free lateral diffusion
leaflet composition difference
transverse motions of lipids needs protein
where are new lipids synthesized?
what happens when a bulge is created from new lipids in the inner leaflet?
nonspecific lipid transporter flips some lipids into the outer leaflet
asymmetry is abolished
what restores membrane asymmetry after lipid movement?
flippase- move things to the inner leaflet
floppase- move things to the outer leaflet
where do cholesterol rafts accumulate?