B2.081 Prework 1 The Fluid Mosaic Model Flashcards Preview

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Flashcards in B2.081 Prework 1 The Fluid Mosaic Model Deck (21)
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1

what are the 6 properties of membranes?

1.components: lipids and proteins
2. amphipathic
3. noncovalent assembly
4. sheetlike
5. fluid
6. asymmetric

2

what are the two classes of phospholipids?

derivatives of glycerol or sphingosine

3

what are the components of a glycerol derived phospholipid?

2 fatty acid tails
glycerol
phosphate
alcohol

4

saturated vs. unsaturated fatty acids

saturated = single bonds, staggered
unsaturated = double bonds, kinked at double bond locations

5

what do alcohols attached to phosphatidate have in common?

charged, polar, or aromatic

6

what is a phosphatidate

phospholipid without alcohol group

7

what are the components of a sphingosine derived phospholipid?

sphingosine
fatty acid
sugar

8

what is the simplest glycolipid?

sphingosine
fatty acid
glucose

9

what are gangliosides?

sphingosine lipids with many sugar residues

10

what happens to amphipathic lipids in water

they assemble into noncovalent structures
monolayer
bilayer
liposome
micelle

11

what is the function of cholesterol?

modulates membrane flexibility/fluidity

12

what are the types of membrane proteins?

integral
peripheral
lipid-modified

13

how are protein islands formed?

integral proteins shift laterally due to binding of signaling proteins

14

how does the membrane mediate cell shape changes?

membrane proteins interact with the cytoskeleton forming a mesh pattern

15

what are cytoskeleton corrals?

limits where membrane proteins can travel by preventing lateral motions

16

what are some sources of membrane asymmetry?

free lateral diffusion
leaflet composition difference
transverse motions of lipids needs protein

17

where are new lipids synthesized?

intracellularly

18

what happens when a bulge is created from new lipids in the inner leaflet?

nonspecific lipid transporter flips some lipids into the outer leaflet
asymmetry is abolished

19

what restores membrane asymmetry after lipid movement?

flippase- move things to the inner leaflet
floppase- move things to the outer leaflet

20

where do cholesterol rafts accumulate?

outer leaflet

21

where are glycol-moieties located?

exoplasmic
either outside a cell or inside an organelle