B2.048 Prework 2 Clinical Presentation Flashcards Preview

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Flashcards in B2.048 Prework 2 Clinical Presentation Deck (12)
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1

what is the most common presentation of childhood DM1?

hyperglycemia without acidosis

2

what is the second most common presentation of childhood DM1?

DKA
30% of patients

3

what increases a patient's likelihood of progressing to DKA?

<6 or from adverse socioeconomic backgrounds

4

what types of patients will be diagnosed before the onset of clinical symptoms?

children with another close family member with DM1

5

what are the diagnostic criteria for diabetes

fasting plasma glucose >126 mg/dL
random venous plasma glucous >200 mg/dL and classic symptoms
plasma glucose >200 mg/dL 2 hours after glucose load of 1.75 g/kg
A1c >6.5% (this criterion more useful in DM2)

6

compare the diagnostic ability of A1c in children and adults

less well established for children
children may have lower values and still have DM1

7

what are differences in body habitus in DM1 vs DM2 patients?

DM2 usually obese
DM1 only 25% overweight

8

what are differences in age of onset in DM1 vs DM2 patients?

DM1 <10 years old
DM2 >10 years old

9

what are differences in family history in DM1 vs DM2 patients?

DM1 10% have affected relative
DM2 75-90%

10

what is acanthosis nigricans

sign of insulin resistance
dark patchy areas of skin

11

what antibody is associated with DM1?

pancreatic antibodies against glutamic acid decarboxylase (GAD65)

12

what are come other causes of diabetes? (not DM1 or DM2)

exocrine disease
endocrine abnormalities in glucose regulation (extra counter regulatory hormone release)
drug induced
monogenic