Flashcards in B2.048 Prework 2 Clinical Presentation Deck (12)
what is the most common presentation of childhood DM1?
hyperglycemia without acidosis
what is the second most common presentation of childhood DM1?
30% of patients
what increases a patient's likelihood of progressing to DKA?
<6 or from adverse socioeconomic backgrounds
what types of patients will be diagnosed before the onset of clinical symptoms?
children with another close family member with DM1
what are the diagnostic criteria for diabetes
fasting plasma glucose >126 mg/dL
random venous plasma glucous >200 mg/dL and classic symptoms
plasma glucose >200 mg/dL 2 hours after glucose load of 1.75 g/kg
A1c >6.5% (this criterion more useful in DM2)
compare the diagnostic ability of A1c in children and adults
less well established for children
children may have lower values and still have DM1
what are differences in body habitus in DM1 vs DM2 patients?
DM2 usually obese
DM1 only 25% overweight
what are differences in age of onset in DM1 vs DM2 patients?
DM1 <10 years old
DM2 >10 years old
what are differences in family history in DM1 vs DM2 patients?
DM1 10% have affected relative
what is acanthosis nigricans
sign of insulin resistance
dark patchy areas of skin
what antibody is associated with DM1?
pancreatic antibodies against glutamic acid decarboxylase (GAD65)