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RDS Test 2 > B8-074 CBCL STI/STD > Flashcards

B8-074 CBCL STI/STD Flashcards

1
Q

neonatal infection with Ng during vaginal delivery causing conjunctivitis

A

ophtalmia neonatorum

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2
Q

why is there no effective vaccine for Ng?

A

antigenic variation of carboxy termini
phase variation of pilin

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3
Q

mechanism of immune evasion for Ng

A

IgA protease

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4
Q

mechanism of toxicity for Ng

A

lipooligosaccharide (LOS) endotoxin

causes symptoms

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5
Q

Thayer-Martin medium

A

Ng

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6
Q

sensitive and specific test for diagnosis of Ng in symptomatic males

A

gram stain

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7
Q

DOC for Ng

A

ceftriaxone

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8
Q

no classic peptidoglycan layer

A

chlamydia

(week Gram stain –> Giemsa stain)

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9
Q

Giemsa stain

A

chlamydia

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10
Q

why are beta-lactam antibiotics ineffective treatment for chlamydia?

A

no peptidoglycan layer

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11
Q

species specific and serovar-defining protein of chlamydia

A

MOMPS

(act as adhesins and implicated in disease manifestations)

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12
Q

auxotrophs dependent on host cell for ATP

A

chlamydia trachomatis

(cause a vacuole: “chlamydial inclusion”)

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13
Q

[…] body is the infectious form of chlamydia trachomatis

(key to extracellular survival)

A

elementary

(reticulate body only found intracellularly)

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14
Q

Ct does not infect epithelial cells of the […]

A

vagina

(lacking receptors?)

important because specimen must contain infected epithelial cells, so should be from urethra or cervix

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15
Q

Ct MOMPs A-C cause

A

trachoma

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16
Q

Ct MOMPs D-K cause

A

genital infections

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17
Q

Ct MOMPs L1-L3 cause

A

lymphogranuloma vereneum

(painful enlarged lymph nodes –> rupture)

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18
Q

leading cause of preventable blindness

A

Ct trachoma

MOMPs A-C

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19
Q

treatment for Ct trachoma

A

oral tetracycline

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20
Q

women with a history of Ng or Ct have an increased risk of sequelae with

A

PID

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21
Q

“inclusion conjunctivitis” in neonates

A

Ct

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22
Q

Ct in neonates can cause pneumonia presenting with a distinct […]

A

staccato cough

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23
Q

DOC for Ct

A

doxycycline 7 days

(single dose azithromycin if tetracyclines are contraindicated)

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24
Q

multiple shallow painful genital lesions

A

HSV

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25
painless papule/ulcer with painful unilateral adenopathy
lymphogranuloma venereum (Amboss: usually painless ulcer resolves in 1 week, then is followed by painful adenopathy 2+ weeks later)
26
painless lesion with firm raised border and regional lymphadenopathy
primary syphillis
27
painless, slowly progressive ulcerative lesion **without** lymphadenopathy
granuloma inguinale (Donovanosis)
28
few, large painful genital lesions
chancroid
29
HSV type [...] is more likely to cause recurrent genital ulcers
2
30
treatment for HSV that has better bioavailability [2]
valacyclovir famciclovir (pts take less often; more $$)
31
gram negative coccobacillus causing chancroid
H. ducreyi (do cry= painful)
32
not common in US, but common worldwide stem may be traveler presenting with STD [2]
chancroid (painful) granuloma inguinale (painless)
33
L1-L3 serotypes of Ct cause
LGV
34
can cause severe proctocolitis in MSM pts
LGV (be vigilent if chlamydia PCR +)
35
ulcer causes inflammatory reaction in both superficial and deep inguinal nodes characteristic "groove sign"
LGV
36
gram negative rod causing granuloma inguinale
Klebsiella granulomatis
37
Donovan bodies on tissue biopsy
granuloma inguinale | coccobacilli are visible as inclusion bodies in macrophages
38
spirochete cause syphilis
treponema pallidum
39
most characteristic finding of secondary syphillis
rash classically diffuse maculopapular of trunk, palms, and soles
40
unusual and severe variant of secondary syphilis rash usually seen in immunocompromised and spares palms/soles
lues maligna
41
asymptomatic syphilis having been acquired in the previous year
early latent (established via last negative test)
42
asymptomatic syphilis having been acquired more than a year ago OR unclear duration
late latent
43
slowly progressive syphilis 5-30 years after initial infection
tertiary syphilis
44
diagnosis of neurosyphilis requires [...] analysis
CSF
45
what stage of syphilis does neurosyphilis typically present?
can occur at any stage spreads to CNS early
46
thick, white "clumpy" vaginal discharge associated with pruritic erythema from excoriation
vaginal candidiasis
47
treatment for vaginal candidiasis
fluconazole
48
treatment for syphilis
penicillin G (if neuro symptoms --> IV)
49
thin, off-white fishy vaginal discharge
bacterial vaginosis
50
diagnosed via clue cells
bacterial vaginosis
51
treatment for BV
metronidazole
52
mucopurlent discharge motile protozoa on wet mount
T. vaginalis
53
treatment of T. vaginalis
metronidazole
54
pt evaluated for cervicitis and all other testing comes back negative
mycoplasma genitalium (underdiagnosed but PCR is becoming more widely available)
55
treatment for mycoplasma genitalium
azithromycin
56
most common and most often asymptomatic STD
chlamydia
57
why is the pt retested for gonorrhea/chlamydia after 3 month?
risk of reinfection
58
UTI pathogens are a common cause of [...] in older men
epididymitis
59
3 complications of PID
infertility tubo-ovarian abscess peri-hepatitis (Fitz-Hugh-Curtis)
60
most common cause of epididymits/orchitis in young males [2]
Ct Ng
61
most common cause of epididymits/orchitis in older males [2]
E coli Pseudomonas
62
presents with localized pain/tenderness over the posterior testis pain relieved with scrotal elevation (+Prehn sign)
epididymitis
63
retesting for gonorrhea/chlamydia should be done in 3 months due to the high likelihood of [...]
reinfection
64
DOC for chancroid
ceftriaxone
65
DOC for LGV
doxycycline | caused by chlamydia
66
DOC for trichomonas
metronidazole (**1 dose orally**) (treat partner as well)
67
DOC for bacterial vaginosis
metronidazole (**7 days**)
68
HPV serotypes associated with genital warts [2]
6, 11
69
HPV serotypes most associated with cancer [2]
16, 18
70
[what stage of syphilis] asymptomatic
latent (early vs. late latent determined based on time since infection)
71
if a patient is asymptomatic, tests positive for syphilis, and we do not know when the infection was acquired, what stage is it?
late latent
72
all sexually active women under 25 should be screened for [...] due the high prevalence in this age group [2]
gonorrhea chlamydia (include HIV if they haven't been screened previously)
73
[gonorrhea/chlamydia] antegenic variation in pilin
gonorrhea
74
[gonorrhea/chlamydia] more likely to present as urethritis with purulent urethral discharge
gonorrhea
75
[gonorrhea/chlamydia] gram negative diplococci on gram stain
gonorrhea
76
DOC for vaginal candidiasis
fluconazole
77
when left untreated, causes subcutaenous granulomas (gummas), tabes dorsalis, and personality changes
syphilis
78
[gonorrhea/chlamydia] can cause reactive arthritis
chlamydia (classic triad: urethritis, conjunctivitis, arthritis; aka Reiters) | can't pee, can't see, can't climb a tree
79
[gonorrhea/chlamydia] can cause a migratory, asymmetric arthritis
gonorrhea
80
what is the bacterial classification of H. ducreyi?
gram negative coccobacillus
81
HSV is a [...] stranded [...]NA virus
HSV is a [double] stranded [D]NA virus
82
culture from reactive arthritis due to chlamydia will be
negative | causes an immune mediated arthritis
83
most accurate test option for Ng or Ct
NAAT of the discharge | but can do urine PCR
84
[gonorrhea/chlamydia] dark brown intracellular inclusion bodies on Giemsa staining
chlamydia
85
what class of antibiotics inhibits the 30S ribosomal subunit?
tetracyclines
86
what class of antibiotics inhibits the 50S ribosomal subunit?
macrolides (-mycins)
87
antibacterial/antiprotozoal agent that damages DNA within pathogens by forming toxic free radicals
metronidazole
88
antifungal agent that inhibits fungal steroid synthesis
fluconazole
89
[gonorrhea/chlamydia] symptoms of neonatal conjunctivitis begin 5-14 days after birth
chlamydia
90
[gonorrhea/chlamydia] symptoms of neonatal conjunctivitis present 2-5 days after birth
gonorrhea (in US, all neonates receive erythromycin eyedrops to prevent)
91
neonatal conjunctivitis due to chlamydia can cause [...] via descending infection
pneumonia
92
[gonorrhea/chlamydia] more likely to cause high fever and purulent discharge
gonorrhea
93
primary virulence factor of Ng
type IV pili
94
complications of PID
ectopic pregnancy tubo-ovarian abscess infertility chronic pain

RDS Test 2 (21 decks)

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