B8-084 HPV

Question 1

area where squamous epithelium of ectocervix meets the columnar epithelium of endocervix

Answer 1

squamocolumnar junction

Question 2

the viral oncogene of HPV inactivates what tumor suppressor gene?

Answer 2

p53

Question 3

which HPV subtypes account for 90% of genital warts? [2]

(condylomata acuminata)

Answer 3

6, 11

Question 4

routine HPV vaccination is recommended to what target age group?

Answer 4

11-12 years

Question 5

E6 inhibits

Answer 5

p53

(loss of tumor suppression)

Question 6

E7 inhibits

Answer 6

pRb

(allows cell cycle progression)

Question 7

does removing genital warts eradicate the HPV infection?

Answer 7

no

Question 8

most commonly used treatment for genital warts due to HPV

Answer 8

imiquimod

Question 9

strongest risk factors for high-grade dysplasia due to HPV

Answer 9

HPV strain (16, 18)
persistent infection (older age)

(co factors: smoking, multiparity, long term contraception, immunosuppression)

Question 10

strains of HPV most likely to cause cervical dysplasia?

Answer 10

16, 18

(also anal cancer)

Question 11

the timeline from cervical dysplasia to cancer is about […] years

Answer 11

10-30

Question 12

CIN 1 is […] grade

Answer 12

low

Question 13

CIN 3 is […] grade

Answer 13

high

Question 14

vaccines are a […] prevention strategy

Answer 14

primary

Question 15

pap smear is a […] prevention stategy

Answer 15

secondary

Question 16

area that you would most expect to find HPV related dysplasia

Answer 16

transformation zone of the cervix

Question 17

the pink, shiny ectocervix is made of […] cells

Answer 17

squamous

Question 18

the beefy red endocervix is made of […] cells

Answer 18

columnar

Question 19

the squamous cells meet the columnar cells at the

Answer 19

squamo-columnar junction

Question 20

area between the original SCJ and the new SCJ is called the

Answer 20

transformation zone

Question 21

guidelines for CIN1 dysplasia

Answer 21

follow up in 1 year with HPV testing

(usually self resolves)

Question 22

HPV associated anal SCC is 30x higher for what patient population?

Answer 22

PLWHIV

Question 23

[…] immediate hypersensitivity is considered a contraindication for HPV vaccine

Answer 23

yeast

Question 24

if pts receive the HPV vaccine under age 15, they receive […] doses

Answer 24

2

6-12 months apart

Question 25

if pts receive the HPV vaccine over age 15, they receive [...] doses

Answer 25

3 0, 1 month, and 6 months

Question 26

strain of HPV that causes the majority of oropharygeal cancers

Answer 26

HPV 16

Question 27

what area of the cervix is most prone to the development of HPV related cancer?

Answer 27

transformation zone

Question 28

HPV subtypes 6, and 11 are most associated with

Answer 28

genital warts

Question 29

most common side effects of the HPV vaccine

Answer 29

arm soreness fainting

Question 30

the 9-valent HPV vaccine protects against what strains?

Answer 30

6, 11, 16, 18, 31, 33, 45, 52, 58

Question 31

viral oncogenes of HPV 18 [2]

Answer 31

E6 and E7