Bacterial Toxins Flashcards
(17 cards)
Pseudomonas aeruginosa toxin
Exotoxin A
Inactivates EF-2
Diphtheria toxin MOA
Inactivates elongation factor 2 (EF-2)
Causes inhibition of protein synthesis
EHEC E Coli toxin
And MOA
Shiga like toxin (SLT)
Inactivates 60s ribosome
Enhance cytokine release leading to
Hemolytic Uremic Syndrome
Hemolytic uremic syndrome cause and symptoms
Enterohemorrhagic E. coli and shigella
Hemolytic anemia
Acute kidney failure
Thrombocytopenia
Difference between Heat Labile and Heat Stable toxin
Labile: over activates cAMP leading to Cl- secretion in gut
Stable: over activate cGMP : decrease reabsorption of NaCl in gut
Both cause watery diarrhea
Bacillus anthracis
Exotoxin and MOA
Edema factor
Mimics cAMP
Vibrio cholerae
Exotoxin
MOA
Symptom
Cholera toxin
Increase cAMP causing Cl- secretion into gut
Rice water diarrhea
What bug secretes toxin that inhibits phagocytosis?
Bordetella pertussis (whooping cough)
Neurotransmitter inhibiting bacteria
Clostridium tetani (tetanospasim) Clostridium botulinum (botulinum toxin)
Lock jaw caused by
Inhibition of GABA neurotransmitter caused by cleaving of SNARE protein (by tetanosporin)
Flaccid paralysis caused by
Botulinum toxin preventing release of Ach at NT junctions
Cause of gas gangrene
Clostridium perfringens (alpha toxin)
Step pyogenes cause
Lysis of RBCs (beta-hemolysis)
Two bugs that cause toxic shock syndrome
Staph aureus (TSST-1) Strep pyogenes (exotoxin A)
Cytokines involved in TSST
IFNgamma
IL2
Endotoxin activates 3 things
1) macrophage: secrete IL1(fever), TNF(fever, hypotension), NO (hypotension)
2) complements: c3a (hypotension, edema), c5a (chemotaxis)
3) tissue factor (coagulation cascade -> DIC)
C. difficile two toxins
Toxin A: enterotoxin
Toxin B: cytotoxin (destroys cytoskeleton)
Cause pseudomembranous colitis
