Basic science

Question 1

Complement cascade

• 2 most active fragments
• effects (3)

Answer 1

C3a and C5a

1) cause release of histamine
2) C5a is chemoattractant for monocytes
3) stimulate IL-1 release

Question 2

Histamine (3 function)

• released by which cells (2)

Answer 2

1) vasodilation
2) increase vascular permeability
3) bronchoconstriction
- mast cells and basophils

Question 3

NO effects (2)

Answer 3

1) vasodilation
2) inhibition of platelet aggregation

Question 4

Leukotrienes

Answer 4

LTE4 - vasoconstriction, bronchoconstriction, increased vascular permeability

LTB4 - chemoattractant and n0 adhesion

Question 5

Prostaglandins

Answer 5

Prostacyclin (PI2) - vasodilation, bronchodilation, inhibit plt

TXA2 - vasoconstriction, bronchoconstriction, plt aggregation

*PI2 and TXA2 are opposites

PGE2 - vasodilation, bronchodilation, pyrexia, immunodepression, used to induce labor

Question 6

IL-2

Answer 6

Produced by CD4 T cells upon TcR binding to Ag, stimualates 1) B cell production of Ig 2) CD8 cytotoxic T cells