Basic wound healing Flashcards Preview

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Flashcards in Basic wound healing Deck (25):
1

Describe first intention healing

Primary closure
Examples: Suture incisions, heals by tissue apposition

2

Describe second intention healing (3 steps)

Granulation
Contraction
Epithelialization

3

5 phases of wound healing (IMPORTANT)

Wounding
Vascular phase
Inflammatory phase
cellular phase
maturation phase

4

5 phases of wound healing (IMPORTANT)

Wounding
Vascular phase
Inflammatory phase
cellular phase
maturation phase

5

What happens in the vascular phase? (4)

Hemorrhage, hemostasis
Endothelial injury
cellular adhesion
coagulation

6

What happens in the cellular phase?

Fibroplasia (proliferation)

7

What happens in maturation phase?

decrease amount and increase quality via cross linking etc

8

What happens in the inflammatory phase?

Inflammatory reaction, localized response elcicted by injury.
Destroys, dilutes or walls off injured tissue to prepare for the repair
Important to remember there is an increase in permeability

9

What substance in important for early permebaility increase in the inflammatory phase?
What comes later on?

Histamine
Serotonin (more significant)

10

What do prostaglandins do? Why is this very pertinant to surgery?

Permeability changes, vasoactive, chemotaxis
NSAIDS block them, not really that important thtough, pain control is more important

11

Common chemotactic agents in inflammatory phase?

cytokines

12

Common chemotactic agents in inflammatory phase?

cytokines

13

What are granulocytes sensitive to? What are 2 of their purposes?

PH
Antibacterial
Proteolytic enzymes

14

What are granulocytes sensitive to? What are 2 of their purposes?

PH
Antibacterial
Proteolytic enzymes

15

Classic signs of inflammation? (4)

redness
heat
swelling
pain

16

3 cytokines that macrophages release?

TGF 2 alpha
TGG beta
IFG-1

17

3 parts of epithelization

Fibrin-fibronectin seal
epithelial migration
epithelial proliferation

18

4 parts of cellular phase

fibroblast infiltration
Ground substance secretion
capillary ingrowth
granulation tissue formation

19

3 major components of granulation tissue

Capillary loop
fibroblast
macrophage

20

Main function of fibroblast infiltration in the cellular phase

Fibrin-Fibronectin scaffold and fibrinolysis

21

3 major process of the maturation phase

crosslinking - aldehyde bonds
Collagen remodelling - collagen remodeling
Decrease cellularity

22

3 surgeon factors contributing to wound healing efficiency

Tissue handling
Procedure duration
Suture material

23

3 major components of the wound microenvironment

oxygen tension
temperature
pH

24

3 major components of the wound microenvironment

oxygen tension
temperature
pH

25

What kind of oxygen tension favors granulation tissue formation?

Low oxygen tension