Basic wound healing Flashcards Preview

Surgery > Basic wound healing > Flashcards

Flashcards in Basic wound healing Deck (25)
Loading flashcards...
1
Q

Describe first intention healing

A

Primary closure

Examples: Suture incisions, heals by tissue apposition

2
Q

Describe second intention healing (3 steps)

A

Granulation
Contraction
Epithelialization

3
Q

5 phases of wound healing (IMPORTANT)

A
Wounding
Vascular phase
Inflammatory phase
cellular phase
maturation phase
4
Q

5 phases of wound healing (IMPORTANT)

A
Wounding
Vascular phase
Inflammatory phase
cellular phase
maturation phase
5
Q

What happens in the vascular phase? (4)

A

Hemorrhage, hemostasis
Endothelial injury
cellular adhesion
coagulation

6
Q

What happens in the cellular phase?

A

Fibroplasia (proliferation)

7
Q

What happens in maturation phase?

A

decrease amount and increase quality via cross linking etc

8
Q

What happens in the inflammatory phase?

A

Inflammatory reaction, localized response elcicted by injury.
Destroys, dilutes or walls off injured tissue to prepare for the repair
Important to remember there is an increase in permeability

9
Q

What substance in important for early permebaility increase in the inflammatory phase?
What comes later on?

A

Histamine

Serotonin (more significant)

10
Q

What do prostaglandins do? Why is this very pertinant to surgery?

A

Permeability changes, vasoactive, chemotaxis

NSAIDS block them, not really that important thtough, pain control is more important

11
Q

Common chemotactic agents in inflammatory phase?

A

cytokines

12
Q

Common chemotactic agents in inflammatory phase?

A

cytokines

13
Q

What are granulocytes sensitive to? What are 2 of their purposes?

A

PH
Antibacterial
Proteolytic enzymes

14
Q

What are granulocytes sensitive to? What are 2 of their purposes?

A

PH
Antibacterial
Proteolytic enzymes

15
Q

Classic signs of inflammation? (4)

A

redness
heat
swelling
pain

16
Q

3 cytokines that macrophages release?

A

TGF 2 alpha
TGG beta
IFG-1

17
Q

3 parts of epithelization

A

Fibrin-fibronectin seal
epithelial migration
epithelial proliferation

18
Q

4 parts of cellular phase

A

fibroblast infiltration
Ground substance secretion
capillary ingrowth
granulation tissue formation

19
Q

3 major components of granulation tissue

A

Capillary loop
fibroblast
macrophage

20
Q

Main function of fibroblast infiltration in the cellular phase

A

Fibrin-Fibronectin scaffold and fibrinolysis

21
Q

3 major process of the maturation phase

A

crosslinking - aldehyde bonds
Collagen remodelling - collagen remodeling
Decrease cellularity

22
Q

3 surgeon factors contributing to wound healing efficiency

A

Tissue handling
Procedure duration
Suture material

23
Q

3 major components of the wound microenvironment

A

oxygen tension
temperature
pH

24
Q

3 major components of the wound microenvironment

A

oxygen tension
temperature
pH

25
Q

What kind of oxygen tension favors granulation tissue formation?

A

Low oxygen tension