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Flashcards in BB pharmacology Deck (11):
1

Mechanisms of opioid withdrawal

Upregulation of opioid peptide dynorphin
Activation of kappa opioid receptors --> reduces dopamine release
More drug needed to get the same effect

2

Ecstasy targets

5-HT uptake system
Dopamine uptake system
5-HT2 receptors
H2 receptors
a2 receptors

3

Ecstasy toxicity

Raised body temperature
DIC
Rhadomyolysis
Increased renal absorption of water
Hyponatraemia
Cerebral oedema

4

Which drug to use for PD?

Mild = MAOb inhibitor
Moderate = dopamine agonist
Severe = L-Dopa +/- COMTI

5

What chromsome is huntingtin found on?

4

6

Where are neurones lost in Huntingdon's disease?

Medium spiny neurones in the stiato-nigral and striato-pallidal pathway --> loss of indirect pathway relative to direct

7

PAG pathway

Anterior cingulate cortex --> PAG
Amygdala --> PAG
PAG --> nucleus raphe magnus (5-HT and enkephlins) and LC (NA) --> dorsal horn

8

Where do opioids act?

Excitatory
- PAG
- NRPG (nucleus reticularis paragigantocellularis)
Inhibitory
- dorsal horn
- peripheral nocioceptors

9

Effects of opiates

Analgesia
Respiratory depression
Pupillary constriction
Sedation
Euphoria
Hypotension

10

First line treatment of neuropathic pain

Amitriptyline
Duloxetine (SNRI)
Gabapentin/pregabalin

11

Treatment of trigeminal neuralgia

Carbamazepine
Baclofen
Phenytoin
Sodium valproate
Clonazepam