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Flashcards in BCM31 Deck (21):
1

Overton

observed only lipophillic enter cell

2

langmuir

studied monolayers in eponymous troough

3

eponymous trough

requires pure water so doesnt interfere with membrane

4

Nmm^2 RBC lipid covers -> off trough

2Nmm^2 = bilayer

5

Gorter and grender

bilayer

6

miscelles

phospholipid shaken with water - suspensions of misclles

7

roles

compartmentalisation
transmission and detection of signals
regulate transport

8

black lipid membrane

aperture made with teflon painted with lipid
- sim thickness to lipid but differ electrically

9

davson and danielli

lipid sandwhich
protein bread
lipid filling

10

robertson

interpret electron micrographs
= 7nm thick
unit membrane
freeze fracture consistent

11

lateral diffusion of lipid

rapid

12

transverse diffusion of lipid

slow

13

mouse cell + human cell
proof

heterokaryon
- mixed after hour
proteins mix on surface

14

singer nicholson

fluid mosaic mode

15

sonicated at 20kh

membranes break into liposomes
drug transport

16

composition myelin nerve sheath

protein 18%
lipid 79%
carb 3%

17

composition erthrocyte

protein 49%
lipid 43%
carbohydrate 8%

18

chloroplast composition

protein 70%
lipid 30%

19

mitochondrion composition

protein 76%
lipid 24%

20

lipid rafts

may mean refinement neccesary
1. more ordered than surroundings
2. float freely in membrane
3. 3/5 X more cholesterol
4. enriched in sphingolipids 50% more
5. long term stability

21

differences between blm and natural

thickness = nat 4-12 black 5-10
resistence nat 10^6-10^9 blm 10^7 -10^13