Biliary Disease And Pathology Flashcards
What stimulates the release of bile?
Cholecystokinin, which is produced by i cells in the duodenum. Bile is produced by canaliculi in the liver and is stored and concentrated in the gall bladder, in order to aid in the digestion of fat
Where is the majority of bile absorbed?
Terminal ileum, to be returned to the liver.
What are the primary bile acids?
Cholic acid and chenodeoxycholic acid, which are synthesised in the liver from cholesterol. Prior to secretion into the duodenum, they are typically conjugated into glycine and taurine.
What are the secondary bile acids?
Formed by the action of intestinal bacteria on primary bile acids, to form deoxycholic acid and lithocholic acid for lipid absorption by enterocytes.
What does bile contain?
Primary and secondary bile acids
Cholesterol
Bilirubin
Phosphatidylcholine
What is the function of bile?
Absorption of fat
Eliminate unnecessary waste products such as cholesterol and bilirubin
Act as a signalling molecule to activate hormone receptors.
How does bilirubin form?
From the breakdown of RBCs, from the haem portion -> biliverdin in the spleen. Biliverdin -> unconjugated bilirubin by bilirubin reductase.
Unconjugated bilirubin requires albumin for transport in the bloodstream to travel to the liver, and become conjugated with glucoronic acid, to form soluble conjugated bilirubin which is released into the bile, and undergo changes by intestinal bacteria to be excreted in the urine and faeces.
What is the form of bilirubin in the urine?
Urobilinogen- this is formed from the action of intestinal bacteria by deconjugating bilirubin.
-.> A portion is reabsorbed in the terminal ileum to return to the liver as biliverdin.
What is the form of bilirubin in the faeces?
Stercobilin, which is formed from the oxidation of urobilinogen.
What is the cause of pre-hepatic jaundice?
Excess breakdown of RBCs
Gilbert Syndrome
Overactive erythropoeisis
What is Gilbert Syndrome?
Recessive autosomal condition where there is a defect that causes the inability to conjugate bilirubin with glucoronic acid, causing pre-hepatic jaundice.
What is the cause of hepatic jaundice?
Liver damage due to infection or cirrhosis
Drugs
Hepatic cancer
Toxins
What is the cause of post-hepatic jaundice?
Gallstones obstructing bile exit.
Cholangiocarcinoma
Strictures
Biliary atresia
Pancreatic cancer.
What is a cholangiocarcinoma?
Cancer of the bile ducts, which leads to post-hepatic jaundice. There is a low survival rate.
What is biliary atresia?
Inflammation and fibrosis of the bile ducts which prevents the flow of bile, that typically occurs in early infancy, and can be considered a congenital condition. Surgical resection is common and this leads to post-hepatic jaundice.
What causes both hepatic and obstructive jaundice?
Primary sclerosing cholangitis, when bile ducts inside and outside the liver become inflamed and become fibrosed, causing narrowing and the blockage of flow.
What are the types of gallstones?
Cholesterol and pigment- Hardening of bile in the gallbladder, due to too much cholesterol, bile salts or bilirubin.
What is cholecystitis?
Inflammation of the gallbladder due to accumulation of bile, typically due to a bilestone blocking the duct which causes pressure build up and presents as sharp pain in the upper right quadrant
What is mucocele?
Prolonged blockage of the cystic duct leads to bile outflow being blocked. The gall bladder distends and reabsorbed bile to be replaced by clear watery mucous, creating an increase in pressure that causes ischaemia of the gallbladder wall and inflammation if it progresses without relief. This stasis increases the risk of bacterial colonisation and can progress to acute cholecystitis and shock.
What is cholesterolosis?
Excessive accumulation of cholesterol within the macrophages of the mucosa and lamina propia walls of the gallbladder, creating polyps and leading to mucous villous hyperplasia.
What is the endocrine function of the pancreas?
Production of insulin and glucagon for blood glucose regulation by cells in the Islets of Langerhaan.
What is the exocrine function of the pancreas?
Acinar cells produce amylase, lipase and the protease trypsin and elastase for digestion of fats, carbohydrates and protein.
What controls pancreatic secretions into the small intestine?
Sphincter of Oddi, formed of smooth muscle.
Where are the digestive enzymes produced from the pancreas released?
Into the duct of Wirsung, which joins with the bile duct at the hepatopancreatic ampulla of Vater, at the major duodenal papilla.
What is an annular pancreas?
Congenital abnormality where a ring of extrapancreatic tissue encases the duodenum.