Flashcards in binding forces in drug receptor interactions Deck (8)
What are the binding forces in drug receptor interactions?
van der waals bond
What are covalent bonds?
two atoms share a pair of electrons in their outer electron shell
What does covalent bindings of drug to receptors result in?
results in long lasting complexes which CANNOT be separated under physiological conditions.
What is ionic bonding?
electrostatic attraction forces between charged ions involving the transfer of one or more electron(s) from one atom to another
can be separated under physiological conditions
What are hydrogen bonds?
proton to accept an electron from donor atoms such as oxygen or nitrogen.
What is a Van der waal bond?
attractive forces between nonpolar molecules.
due to the electrical attraction between the nucleus of one molecule and the electrons of another
very weak but causes affects when molecules are together
What are hydrophobic interactions?
tendency of nonpolar molecules to interact with one another
important for lipid soluble drugs