binding forces in drug receptor interactions Flashcards

1
Q

What are the binding forces in drug receptor interactions?

A
covalent bonds 
ionic bonds 
hydrogen bonds 
van der waals bond 
hydrophobic interactions
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2
Q

What are covalent bonds?

A

two atoms share a pair of electrons in their outer electron shell

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3
Q

What does covalent bindings of drug to receptors result in?

A

results in long lasting complexes which CANNOT be separated under physiological conditions.

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4
Q

What is ionic bonding?

A

electrostatic attraction forces between charged ions involving the transfer of one or more electron(s) from one atom to another

can be separated under physiological conditions

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5
Q

What are hydrogen bonds?

A

proton to accept an electron from donor atoms such as oxygen or nitrogen.

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6
Q

What is a Van der waal bond?

A

attractive forces between nonpolar molecules.

due to the electrical attraction between the nucleus of one molecule and the electrons of another

very weak but causes affects when molecules are together

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7
Q

What are hydrophobic interactions?

A

tendency of nonpolar molecules to interact with one another

important for lipid soluble drugs

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8
Q

What type of interactions does drug and receptors undergo?

A

not caused by any single type of receptor.

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