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Flashcards in receptor superfamilies and signal transduction mechanisms Deck (19)
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1

What is an agonist?

an agent that binds a receptor and produces a signal

2

what must happen for a receptor to produce a signal?

it must be stimulated by am agonist?

3

what is primary agonist?

a drug binds to the same recognition site as the endogenous agonist

4

What is a anagonist?

An agent that binds a receptor and prevents the agonist to produce an effect

5

What are the four superfamilies of receptors?

Ionotropic receptors
metabotropic receptors
Enzyme linked receptors
intracellular receptors

6

What are metabotropic receptors?

receptors connected to G proteins

7

Which events does ionotropic receptors control?

the fastest synaptic events in the nervous system

8

What is the ion conductance controled by in ionotophic receptors?

ligand binding (ligand gated)
Voltage change (voltage gated)
secondary messenger regulated

9

What is the function of Gproteins?

couple stimulation of receptors

10

What are characteristics of g proteins?

alpha, beta. gamma receptors
seven trasnsmembrane helices
4 intracellular and extracellular domains

11

What type of signals use enzyme linked receptors?

Growth factors
insulin
cytokines

12

What receptors or often enzyme linked receptors?

tyrosine kinases
tyrosine phosphotase

they dimerize upon activation

13

Where are intracellular receptors?

mobile receptors that are soluble constituents of the cytosol

14

What the types of intracellular receptors?

Type 1
type 2

15

Where type 1 intracellular receptor found?

in cytosol

used for sex hormones
glucocorticoids
mineralocorticoids

16

Where is type 2 intracellular receptor found?

in the nucleus

used for thyroid hormone
vitamins A,D

17

What most a agonist be in order to bind to a intracellular receptor?

must be lipid soluble, must cross the lipid membrane

18

What are the domains of intracellular receptors?

C-binding domain
N - regulatory domain
DNA binding domain -

19

What is the effect of intracellular receptors?

They are slow receptors because take hours or days for an effect