Flashcards in receptor superfamilies and signal transduction mechanisms Deck (19)
What is an agonist?
an agent that binds a receptor and produces a signal
what must happen for a receptor to produce a signal?
it must be stimulated by am agonist?
what is primary agonist?
a drug binds to the same recognition site as the endogenous agonist
What is a anagonist?
An agent that binds a receptor and prevents the agonist to produce an effect
What are the four superfamilies of receptors?
Enzyme linked receptors
What are metabotropic receptors?
receptors connected to G proteins
Which events does ionotropic receptors control?
the fastest synaptic events in the nervous system
What is the ion conductance controled by in ionotophic receptors?
ligand binding (ligand gated)
Voltage change (voltage gated)
secondary messenger regulated
What is the function of Gproteins?
couple stimulation of receptors
What are characteristics of g proteins?
alpha, beta. gamma receptors
seven trasnsmembrane helices
4 intracellular and extracellular domains
What type of signals use enzyme linked receptors?
What receptors or often enzyme linked receptors?
they dimerize upon activation
Where are intracellular receptors?
mobile receptors that are soluble constituents of the cytosol
What the types of intracellular receptors?
Where type 1 intracellular receptor found?
used for sex hormones
Where is type 2 intracellular receptor found?
in the nucleus
used for thyroid hormone
What most a agonist be in order to bind to a intracellular receptor?
must be lipid soluble, must cross the lipid membrane
What are the domains of intracellular receptors?
N - regulatory domain
DNA binding domain -