Bleeding

Question 1

Tranexamic acid

Indications

Answer 1

• Local fibrinolysis
• Menorrhagia
• Hereditary angioedema
• Epistaxis (nose bleed)- 1g TDS
• Prevention and treatment of significant haemorrhage following trauma

Question 2

Tranexamic acid

MOA

Answer 2

• Anti-haemorrhagic activity by inhibiting fibrinolytic properties of plasmin
• The activity of tranexamic acid-plasmin complex on the activity on fibrin is lower than the activity of free plasmic alone

Question 3

Tranexamic acid

adverse effects

Answer 3

• Thrombosis
• N&V
• Seizure (more common at high doses)
• Visual changes

Question 4

Tranexamic acid

Warnings

Answer 4

• Contraindications
  
  • Fibrinolytic conditions following disseminated intravascular coagulation (unless pre-dominant activation of the fibrinolytic system with severe bleeding)
  • History of convulsions
  • Thromboembolic disease
• Cautions
  
  • Irregular menstrual bleeding (Establish cause first)
  • Haematuria
  • Receiving oral contraceptives (Increased risk of thrombosis )

Question 5

Tranexamic acid

Interactions

Answer 5

• Contraceptive pills- increased the risk of thrombus formation