bleeding disorders Flashcards
(15 cards)
What assessment tool is used for bleeding history
ISTH bleeding assessment tool score
What kind of bleeding is associated with platelet disorders
Mucosal:
- Bruising
- Epistaxis
- Purpura
- Menorrhagia
- GI
What bleeding is associated with coagulation factor
Articular:
- Muscle haematoma
- CNS
What kind of genetic condition is Haemophilia A and B
X-linked
What are the clinical features of haemophilia
- Haemarthrosis
- Muscle haematoma
- CNS bleeding
- Retroperitoneal bleeding
- Post surgical bleeding
How is haemophilia diagnosed
Haematology - isolated prolonged APTT but a normal PT
- reduced FVIII in haemophilia A
- Reduced fIX in haemophilia B
What is the treatment of haemophilia
- Recombinant factor concentrates
- Prophylaxis
- Emicizumab for haemophilia A
- Desmopressin for mild haemophilia A in younger people
- Physiotherapy
- Analgesia
- Synovectomy
- Joint replacement
How does emicizumab work
It mimicks the function of missing factor VIII - can be used in haemophilia A
What is required for a diagnosis of Von Willebrand disease
vWF level < 30
What is the treatment for Von Willebrand disease
- vWF recombinant concentrate with or without factor VIII
DDAVP - Desmopressin
- Tranexamic acid
What are the common presentations of thrombocytopenia
- Petechia
- Ecchymosis
- Mucosal bleeding
What is the key investigation finding that will raise suspicion of ITP- immune thrombocytopenia
Isolated thrombocytopenia but a normal blood film otherwise
What is the management of ITP - immune thrombocytopenia
- Steroids or immunoglobulins short term
- Long term:
Thrombopoetin analogues such as eltrombopag
OR
Immunosuppresion
What is seen in the clotting screen for liver failure
Prolonged PT, APTT and reduced fibrinogen
