BLISTERING DISEASES

Question 1

1. Identify.
2. What blistering condition is this observed?
3. What is the targeted autoantigen?

Answer 1

1. Acantholysis - Loss of cohesion between the keratinocytes
2. Pemphigus foliaceus
3. Desmoglein 1

Question 2

Answer 2

Left to right

• Impetigo
• SSSS
• Sneddon-Wilkinson

Question 3

1. Diagnosis
2. Mutation?

Answer 3

1. Hailey-Hailey Disease
2. ATP2C1

Question 4

1. Diagnosis
2. Mutation?

Answer 4

1. Darier Disease
2. ATP2A2

Question 5

Give DDx for Subepidermal blister with neutrophilic infiltrates

Answer 5

• Dermatitis herpetiformis
• LABD
• Bullous LE
• LCV
• Cellulitis

Question 6

Give DDx for Subepidermal blister with eosinophilic infiltrates

Answer 6

• Bullous pemphigoid
• Cicatricial pemphigoid
• Herpes gestationis
• Arthropod bite

Question 7

Give DDx for Subepidermal blister with cell poor infiltrates

Answer 7

• Epidermolysis bullosa
• PCT
• Cell poor pemphigoid
• Bullous amyloidosis
• Coma blister

Question 8

Answer 8

Question 9

Answer 9

Dermatitis Herpetiformis

• Subepidermal vesiculation
• Neutrophils abscess in tips of dermal papillae
• Epidermal Transglutaminase-3

Question 10

Answer 10

Question 11

Answer 11

Porphyria Cutanea Tarda

• Subepidermal bulla
• Little or no inflammatory cells
• Festooningpreserved dermal papillae

Question 12

Answer 12