LYMPHOMA

Question 1

What stain can be used to identify B-cells

Answer 1

CD 20

Question 2

What stains can be used to identify T cells

Answer 2

CD4, CD3, CD8

Question 3

Infiltrate pattern in CTCL

Answer 3

Epidermotropic
Dermal
Subcutaneous

Question 4

Infiltrate pattern in MF

Answer 4

Epidermotropic

Question 5

Answer 5

Question 6

Answer 6

Question 7

Answer 7

• less epidermal involvement in tumor stage

Question 8

Diagnostic criteria of Sezary syndrome

Answer 8

*conal rearrangement by PCR or Southern Blot - in the skin or blood

Question 9

*may have similar histopath findings with MF

Question 10

What are the features of Type A Lymphomatoid papulosis?

Answer 10

*there is a wedge-shaped infiltrate int he dermis
*Necrosis may be present in the dermis
*<75% CD30+ cells

Question 11

Features of Primary Cutaneous Anaplastic Large-cell Lymphoma

Answer 11

Question 12

Features of Subcutaneous Panniculitis-like T-cell lymphoma (Mature cytotoxic α/β T-cell)

Answer 12

Question 13

Stains positive in Subcutaneous Panniculitis-like T-cell lymphoma (Mature cytotoxic α/β T-cell)

Answer 13

Question 14

Immunophenotype of CTCL

Answer 14

Question 15

Stain that can highlight centrocyte and centroblast

Answer 15

BCL6 and CD10

Question 16

Cells present in Germinal center of a lymphoid follicle

Answer 16

• Centrocyte
• Centroblast
• Follicular dendritic cells - CD21 (+)
• Tingible macrophages - macrophages with engulfed apoptotic B cells

Question 17

Characterize the mantle zone of a lymphoid follicle

Answer 17

• ring of surrounding small round B cells
• darker compared to germinal center

Question 18

Marker that can highlight the mantle zone

Answer 18

BCL2

Question 19

Characterize the marginal zone of the lymphoid follicle

Answer 19

• ring of pale staining cells peripheral to mantle zone
• resembles centrocytes

Question 20

Characterize a Cutaneous Lymphoid Hyperplasia

Answer 20

*intact follicular dendritic cells and centrocytes and centroblasts inside the germinal center
*High Ki-67

Question 21

Characterize a Follicle-center B-cell Lymphoma

Answer 21

Question 22

Answer 22

Question 23

Question 24

*(+) perifollicular accentuation

Answer 24

Question 25

## Footnote *(-) CD10 and CD21 * high ki-67

Answer 25

Question 26

Immunophenotype of B cell lymphoma

Answer 26

Question 27

Question 28