PANNICULITIS AND CUTANEOUS VASCULITIS

Question 1

The pathology in A is mostly where? Septa or Lobules?

Answer 1

SEPTA

Question 2

Answer 2

Erythema Nodosum

• Mostly SEPTAL inflammation
• May have superficial and deep perivascular inflammation

Question 3

Identify. What condition is this seen?

Answer 3

Miescher’s Granuloma: Histiocytes arranged radially around a stellate or banana-shaped cleft or multinucleate giant cells with a similar cleft

Erythema Nodosum

Question 4

Answer 4

Subcutaneous Fat Necrosis of the Newborn

• Adipocyte cytoplasm becomes eosinophilic
• Needle-shaped clefts arranged radially either replacing the adipocyte or within multinucleated giant cells.

Question 5

CLOSE HISTOLOGIC DIFFERENTIAL OF Subcutaneous Fat Necrosis of the Newborn

Answer 5

Sclerema Neonatorum

Question 6

Differentiate Vasculitis vs Vasculopathy

Answer 6

Question 7

give examples of small vessel vasculitis

Answer 7

Question 8

Give examples of medium vessel vasculitis

Answer 8

Question 9

Give examples of large vessel arteritis

Answer 9

Question 10

Diagnosis? What are the 4 important histologic features?

Answer 10

Leukocytoclastic vasculitis

1) Neutrophils

2) Neutrophilic nuclear dust (karyorrhexis) (Leukocytoclasia)

3) Extravasated erythrocytes

4) Fibrinoid necrosis/ fibrin deposition - eosinophilic deposition of the fibrin around the blood vessel

Question 11

IMPORTANT HISTOLOGIC FEATURE of leukocytoclastic vasculitis

Answer 11

Fibrin deposition / fibrinoid necrosis

Question 12

Grenz Zone + Vasculitis with numerous eosinophils + plasma cells

Answer 12

Granuloma faciale

Question 13

Vasculitis + dense infiltrates of neutrophils + eosinophils + fibrosis

Answer 13

Erythema elevatum diutinum

Question 14

Answer 14

Medium-vessel VASCULITIS: Polyarteritis Nodosa (PAN)

• Medium-sized arteritis on deep dermis or subcutaneous area

*Medium sized vessel: located in the deep dermis or subcu

Question 15

What is the DIF finding of Henoch-Schonlein Purpura

Answer 15

IgA Deposition in blood vessel walls

Question 16

1. Pattern?
2. Diagnosis?

Answer 16

1. Vasculitis
2. Polyarteritis nodosa

*medium-sized vasculitis