DPS REVIEW Flashcards
(96 cards)
1
Q
A
Langerhans Cells
- Marrow-derived, dendritic antigen presenting cells
- Clear cells in the suprabasal area
- Folded nucleus, no tonofilaments, desmosomes
- Contains Birbeck granules
- 2 to 4% of the epidermis
- Chronic and repeated exposures to UV depletes LCs
2
Q
Stains for langerhans cells
A
- S100
- CD1a
- CD 207 (Langerin)
- CD68
3
Q
Identify. What condition is this seen?
A
Max-Joseph Space
Lichen Planus
4
Q
Identify. What condition is this seen?
A
Civatte Bodies
Lichen Planus
5
Q
Loss of cell–cell adhesion
A
Acantholysis, pemphigus vulgaris
6
Q
A
Anaplasia, Bowen’s disease
Atypical nuclei (abnormal size, shape, staining) and pleomorphism (variation in nuclear characteristics)
7
Q
seen in?
A
sarcoidosis or berylliosis
- Collections of eosinophilic material seen in sporotrichosis
- Also refers to star-shaped intracytoplasmic inclusions seen in giant cells of sarcoidosis or berylliosis or other granulomatous processes
8
Q
Caterpillar body - Pale pink linear basement membrane material within epidermis
Seen in?
A
porphyria cutanea tarda
- Represents degenerated type IV collagen
9
Q
A
Dermatofibroma
Collagen fibers surrounded by histiocytes/spindle cells (collagen balls)
10
Q
A
Corps ronds/grains, Darier’s disease
- Corps ronds = rounded nucleus with halo of pale to pink dyskeratotic cytoplasm
- Grain = dark blue flattened nucleus surrounded by minimal cytoplasm
- Dyskeratosis = abnormal, individual-cell keratinization
11
Q
A
Cornoid lamellae, porokeratosis
45° angle parakeratosis in a column above a focus with a diminished granular layer and underlying dyskeratotic cells
12
Q
A
Epidermotropism
Lymphocytes in epidermis with relative absence of spongiosis: term usually reserved for mycosis fungoides
13
Q
A
Kamino body
Dull pink to amphophilic basement membrane material within the epidermis in a Spitz nevus
14
Q
A
Medlar Body
- seen in Chromomycosis
- Brown, round structure resembling overlapping copper pennies
- Divide by septation, resembling a hot-cross bun
15
Q
A
Pagetoid cells and pagetoid scatter, Paget’s disease
16
Q
A
Papillary mesenchymal body
Structure that resembles the whorl of plump mesenchymal cells normally present in the hair papilla (seen in trichoblastoma and trichoepithelioma)
17
Q
A
Shadow cells, pilomatricoma
18
Q
18/M presented with generalized pustules
A.What is the diagnosis?
B.What is the most common drug associated with this condition?
A
19
Q
15/F presented with a scaly plaque on the trunk
A.What is the diagnosis?
B.What special stain will you request?
A
20
Q
35/F presented with multiple erythematous plaques with thick whitish scales.
A.What is the diagnosis?
B.Identify the pointed structure.
A
21
Q
32/M presented with erythematous scaly plaques
A. What is the diagnosis?
B. Give one special stain that will aid you with the diagnosis.
A
22
Q
18/F presented with erythematous plaques
A.What is the diagnosis?
B.What is the causative factor?
A
23
Q
32/M presented with multiple hyperpigmented papules on the anterior legs
A.What is the diagnosis?
B.What is a positive finding under a polarized microscope?
A
24
Q
Skin colored papules
A. What is the diagnosis?
B. Give one common location.
A
25
12/M presented with multiple reddish-blue papules on the anterior trunk and thigs
A.What is the diagnosis?
B.What is the associated genetic condition?
26
15/F presented with multiple skin-colored to violaceous grouped papules on the buttock, right
A.What is the diagnosis?
B.Identify the pointed structure.
27
7/M presented with an erythematous and exophytic papule on the cheek.
A.What is the diagnosis?
B.Give one positive immunohistochemical stain.
28
43/M presented with generalized erythematous and edematous plaques.
A.What is the diagnosis?
B.What is the etiology?
29
Skin colored nodule
A. What is the diagnosis?
B. Identify the pointed structure
30
56/F erythematous plaques on the chest.
A.What is the diagnosis?
B.What immunohistochemical stain would be positive?
31
Erythematous plaque in the abdomen
A. What is the diagnosis?
B. Give 1 etiologic factor
32
65/F presented with a solitary ulcerating brownblack nodule on the leg.
A.What is the diagnosis?
B.Give one positive immunohistochemical stain.
33
Multiple slightly pigmented papules
A. What is the diagnosis?
B. Give the causative agent
34
26/F erythematous nonscaly annular plaque on the extensor arm.
A.What is the diagnosis?
B.What is the specific inflammatory pattern?
35
A. What is the diagnosis?
B. Identify the pointed structure
36
17/M presented with pale erythematous firm nodule on the chest.
A.What is the diagnosis?
B.If an elastic stain was requested, what would the result be?
37
Painful nodule on the arm
A. What is the diagnosis?
B. Give 1 stain to aid in your diagnosis
38
24/F presented with hyperpigmented plaque on the trunk.
A.What is the diagnosis?
B.If CD34 was requested, what would the result be?
39
52/F presented with multiple hyperpigmented brown firm nodules on the leg
A.What is the diagnosis?
B.Give one positive immunohistochemical stain.
40
Skin colored nodule
A. What is the diagnosis?
B. Give an immunohistochemical stain to aid in the diagnosis
41
24/F presented with a firm nodule on the scalp
A.What is the diagnosis?
B.What type keratinization is present?
42
NODULE ON THE 5TH DIGIT OF THE RIGHT HAND
A. WHAT IS THE DIAGNOSIS?
B. Give a special stain to aid in your diagnosis
43
22/F presented with multiple skin-colored papules on the trunk
A.What is the diagnosis?
B. Where is the tumor derived?
44
80/F presented with multiple tense blisters
A.What is the diagnosis?
B.What is the target antigen?
45
Multiple erythematous, plaques with thick adherent yellowish scales and crusts and erosions
A. What is the diagnosis?
B. What are the antigens involved in this condition?
46
5/M presented with targetoid plaques on the hands and trunk.
A.What is the diagnosis?
B.What is the most common etiology in pediatrics?
47
33/F presented with violaceous patches associated with shearing of the skin.
A.What is the diagnosis?
B. What is the human leukocyte antigen associated with the intake of carbamazepine?
48
Multiple itchy papules
A. What is the diagnosis?
B. Identify the pointed structure
49
5-year-old female with lesions on the legs and abdominal pain
A. What is the pattern?
B. Give the clinical diagnosis
50
Nodule on the leg
A. What is the diagnosis?
B. Give one histologic differential diagnosis
51
75/M presented with ulcerated brown-black nodule on the cheek
A.What is the specific diagnosis? B.What is the primary gene mutation involved?
52
35/M presented with a friable erythematous nodule on the left sole
A.What is the diagnosis?
B.Where is the tumor derived?
53
A. What is the diagnosis?
B. This tumor is associated with what mutation?
54
67/M presented with flesh-colored to light brown domeshaped papule on the left nasal ala.
A.What is the diagnosis?
B.What is the most common mutation for this proliferation?
55
22/F presented with a skincolored dome-shaped papule on the face
A.What is the diagnosis?
B. Identify the pointed structure.
56
45/F presented with a skincolored flat papules on the periorbital area
A.What is the diagnosis?
B. Where is the tumor derived?
57
56/F presented with a solitary flesh dome-shaped papule on the scalp.
A.Where is the tumor derived?
B. What syndrome is associated with multiple lesions?
58
3/M presented with a firm papule on the left cheek.
A.What is the associated mutation? B.Identify the pointed stricture.
59
Hyperkeratotic erythematous nodule
A. What is the diagnosis?
B. Give an immunohistochemical stain to confirm your diagnosis
60
A. What is the diagnosis?
B. Give 1 syndrome associated with multiple of this tumor
61
63/F presented with a solitary flesh dome-shaped papule on the tip of the nose.
A.What is the diagnosis?
B. What is the mutation of the syndrome associated with this condition?
62
30 year old female with skin colored plaque
A. What is the diagnosis?
B. Where is this tumor derived from?
63
Multiple nodules on the face
A. What is the diagnosis?
B. Give 1 stain to aid in your diagnosis
64
Sample taken from a vesicle
A. What is the diagnosis?
B. What is the possible etiology of these reactive changes?
a. Bacterial cytopathic changes
b. Viral cytopathic changes
c. Inflammatory changes
d. Auto-immune changes
65
ITCHY PAPULES
A. WHAT IS THE DIAGNOSIS?
B. Give the etiologic agent.
66
75/F presented a solitary nodule on the face.
A.Identify the pattern?
B. What is the most likely cell implicated and give the immunohistochemical stain.
67
Skin colored plaque since birth
A. What is the diagnosis?
B. What is the most common malignant tumor associated with this tumor?
68
Keratins in the basal layer
Keratin 5 and 14 (LMWCK)
69
Keratins in the spinous layer
Keratin 1 and 10 (HMWCK)
70
skin layer known as the “Zone of maturation”
s. spinosum
71
skin layer known as the “Mature keratin-forming transitional zone”
s. granulosum
72
normal MELANOCYTES TO KERATINOCYTES RATIO
~1:10
73
stains for merkel cells
* CK20 – most sensitive and specific
* CAM 5.2
* INSM1 – novel stain
73
EPITHELIAL MARKERS
* AE1/AE3
* pan-CK
* EMA
* Ber-EP4
74
NEUROENDOCRINE MARKERS
* CHROMOGRANIN
* SYNAPTOPHYSIN
* Calcitonin
* VIP
* Somatostatin receptor
75
1. Identify
2. location on the body
3. location in the skin
4. function
1. Meissner's corpuscles
2. palms and soles
3. dermal papilla
4. touch receptors
76
1. Identify
2. location on the body
3. location in the skin
4. function
1. Pacinian corpuscles
2. fingers and toes
3. subcutaneous
4. pressure receptors
77
1. Identify
2. They empty into hair follicle at what level
1. sebaceous gland
2. Glands empty into hair follicle at level of the follicular infundibulum
78
give differential diagnosis for SUBCORNEAL PUSTULES
CATPISS
* Candida
* AGEP
* Tinea
* Pustular psoriasis/ pemphigus foliaceus
* Impetigo
* Sneddon-Wilkinson Disease or subcorneal pustular dermatosis (SPD/)
* SSSS
79
differential diagnoses of NEUTROPHILS IN THE STRATUM CORNEUM
PTICSS
* Psoriasis
* Tinea
* Impetigo
* Candida
* Seborrheic dermatitis
* Syphilis
80
glands with Merocrine secretion
eccrine and apocrine glands
81
Stains for adnexal tumors
82
Adnexal tumors that originates in the acrosyringium
Poroma family (Poroma, hidroacanthoma simplex, hidradenoma, dermal duct tumor)
83
origin or differentiation of syringoma
intradermal duct of either the eccrine or apocrine gland
84
tumor that originate from the eccrine gland
Eccrine hidrocystoma
85
tumor that originate from the apocrine gland
* Apocrine hidrocystoma
* Syringocystadenoma papilliferum
* Hidradenoma papilliferum
86
tumors that originate from both the eccrine and apocrine glands
Spiradenoma
Cylindroma
Spiradenocarcinoma
87
origin or differentiation of steatocystoma
Sebaceous duct
88
origin of sebaceous hyperplasia
MATURE sebaceous glands
89
tumors originating from sebaceous gland
Sebaceous adenoma, sebaceoma and sebaceous carcinoma
90
91
92
Papillomatosis differentials
"CAVES"
Confluent and reticulated papillomatosis,
Acanthosis nigricans,
Verruca vulgaris,
Epidermal nevus,
Seborrheic keratosis
93
stain for smooth muscle
* h-caldesmon
* desmin
* a-SMA (smooth muscle actin)
* muscle specific actin (MSA)
94
SYNDROMES WITH TRICHOBLASTOMAS/ TRICHOEPITHELIOMAS
95
