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Flashcards in Blood 2 Deck (137)
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2

The 'BLEEDING' from many small vessels is known as what?

THROMBOCYTOPENIA PURPURA

(*HINT - 'PURPURA' = PURPLE)

3

How can 'THROMBOCYTOPENIA' be treated?

TRANSFUSIONS OF PACKETED PLATELETS

4

When the 'ENDOTHELIAL LINING' of a vessel is exposed to 'COLLAGEN PROTEINS', a process of 3 separate but overlapping mechanisms occurs. What are they?

1. VASOCONSTRICTION
2. PLATELET PLUG FORMATION
3. FORMATION OF BLOOD CLOT

5

'VASOCONSTRICTION' is 'STIMULATED' by what during the 'BLOOD CLOTTING' process?

SEROTONIN

6

What causes 'VASOCONSTRICTION' during 'BLOOD CLOTTING'? What are some of the characteristics?

(*There are 3 things)

1. VESSEL WALL IS CUT OR BROKEN
2. MUSCLES STIMULATED TO CONTRACT
3. BLOOD LOSS IS 'DECREASED'

7

TRUE OR FALSE

In the absence of 'VESSEL DAMAGE', platelets are attracted to each other.

FALSE

'PLATELETS' are 'repelled' from each other during 'VESSEL DAMAGE'

8

What does the 'PLATELET PLUG' temporarily do?

TEMPORARILY 'CLOSES' THE VESSEL UNTIL CLOTTING MECHANISMS CAN FORM A CLOT.

9

What is the 'PLATELET PLUG' strengthened by?

PROTEIN FIBERS CALLED 'FIBRIN'

10

What are the two 'pathways' that result in the formation of 'FIBRIN'?

1. INTRINSIC PATHWAY (Inside)
2. EXTRINSIC PATHWAY (Outside)

11

What is the main difference between 'EXTRINSIC' and 'INTRINSIC' pathways?

1. EXTRINSIC = TISSUE DAMAGE
2. INTRINSIC = VASCULAR DAMAGE

12

What 'CLOTTING FACTORS' does the 'INTRINSIC PATHWAY' have that the 'EXTRINSIC PATHWAY' does not?

FACTOR 9, 11 AND 12

13

Where are 'PROTHROMBIN' and 'FIBRINOGEN' made?

(*Hint - They are 'PLASMA PROTEINS')

MADE IN THE LIVER

14

What 'CONVERTS' 'PROTHROMBIN' to 'THROMBIN'?

CALCIUM

15

When 'THROMBIN' reacts with 'FIBRINOGEN' what is the result?

FIBRIN CLOT

16

What is the 'COLOR' of a 'CLOT'?

NO COLOR

CLOT IS DERIVED FROM 'PLASMA' CONSTITUENTS

*THE RED COLOR COMES FROM 'RBCs' THAT BECOME TRAPPED.

17

'CLOT RETRACTION' is also referred to as what?

SYNERESIS

18

'PLATELETS' play a role in bringing what closer together?

FIBRIN THREADS CLOSER TOGETHER

19

Why is 'CLOT RETRACTION' important?

DURING 'INTRAVASCULAR CLOTS' THE CLOT IS ABLE TO PULL AWAY FROM THE WALL AND 'RESTORE BLOOD FLOW'

ALLOWS CLOT TO 'SHRINK IN SIZE' AFTER TIME

20

TRUE OR FALSE

CLOTS DO NOT SHRINK IN SIZE

FALSE

'CLOT RETRACTION' OR 'SYNERESIS' OCCURS BY BRINGING 'FIBRIN' THREADS CLOSER TOGETHER.

21

What is the clotting factor 'NUMBER' for 'FIBRINOGEN'?

I

22

What is the clotting factor 'NUMBER' for 'PROTHROMBIN'?

II (2)

23

What is the clotting factor 'NUMBER' for 'TISSUE THROMBOPLASTIN'?

III (3)

24

What is the clotting factor 'NUMBER' for 'CALCIUM'?

IV (4)

25

What is the clotting factor 'NUMBER' for 'ANTIHEMOPHILIC GLOBULIN'?

VIII (8)

26

What is the clotting factor 'NUMBER' for 'CHRISTMAS FACTOR'?

IX (9)

27

What is the clotting factor 'NUMBER' for 'FIBRIN STABILIZING FACTOR'?

XIII (13)

28

What is the 'NAME' for clotting factor 'I'?

FIBRINOGEN

29

What is the 'NAME' for clotting factor 'II'?

PROTHROMBIN

30

What is the 'NAME' for clotting factor 'III'?

TISSUE THROMBOPLASTIN

31

What is the 'NAME' for clotting factor 'IV'?

CALCIUM