Blood Borne Viruses Flashcards
what are the different route of transmission of blood borne viruses
Penetrative sex
contaminated blood
vertical transmission ( mother to child)
What can chronic hep B lead to
Cirrohsis
Heapatocellular carcinoma
What is cirrhosis
Irreversible form of liver injury where the liver is replaced by scar tissue
What is hepatocellular carcinoma
Hep B carriers
200x more likely to develop liver cancer
Diagnosis of Hep B
Antigen positive test
HB core IgM - is evidence of recent infection
anti-HB Ag is evidence of immunity
Treatment for HBV
Anti viral therapy- tenofovir
Interferons
What virus is HCV part of?
flavivirus family
single stranded RNA virus
most common form of transmission for HCV?
Blood contamination
Diagnosis of HCV
serological assays to detect HCV antibody
RNA detection
Genotype analysis
Treatment for HCV
Protease inhibitors
Polymerase inhibitors
What type of virus is HIV
retro virus
what cells does HIV effect
Immune cells
CD4 Lymphocytes
Macrophages
Why are HIV patients often immunosuppressed
Due to the reduction in T cell function
Primary signs of HIV illness
Fever
Malaise
lymphadenopathy
Treatment for HIV
anti viral retrotherapies
-nucleoside reverse transcriptase
inhibitors
- protease inhibitors
