Blood Brain Barrier and Blood Supply Flashcards Preview

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Flashcards in Blood Brain Barrier and Blood Supply Deck (15):

What substances can cross the BBB?

Oxygen, Carbon dioxide and lipid soluble molecules all cross by diffusion. Glucose crosses by carrier mediated transport


Describe the circumventricular organs.

1. Areas without BBB
2. Primarily around 3rd and 4th ventricles
3. Lack tight junctions


Describe the Blood-CSF barrier

1. Cuboidal epithelial cells and endothelial cells


Describe the blood supply of the spinal cord

1. Anterior spinal artery
2. Posterior spinal artery
3. Artery of Adamkiewicz


Discuss the Anterior spinal artery

Supplies anterior cord and lateral corticospinal tracts. Occlusion results in bilateral weakness


Discuss the Posterior spinal artery

Paired; Supplies posterior columns and lateral corticospinal tracts. Occlusion results in sensory deficits


Discuss the Artery of Adamkiewicz

Spinal cord watershed area in the lower thoracic and upper lumbar region. May be damaged in aortic surgeries.


Describe the blood supply of the brain.

The parts:
1. Anterior circulation
2. Posterior circulation
3. Circle of Willis


Explain the Anterior circulation of the brain.

Each internal carotid gives off ophthalmic, Posterior communicating and anterior choroidal arteries before dividing into the anterior and middle cerebral arteries.


Explain the Posterior circulation of the brain.

The vertebral arteries arise from the subclavian artery


Explain the Circle of Willis

Formed by anastomoses of branches of internal carotid arteries and terminal branches of the basilar artery; includes
1. Posterior/Anterior cerebral arteries
2. Posterior/Anterior communicating arteries


What area does the Anterior Cerebral artery supply?

Medial surface of hemisphere; Leg/foot area of motor and sensory cortex.


What area does the Middle Cerebral artery supply?

Lateral convexity of hemisphere, including language areas, motor and sensory cortex. Disruption causes contralateral hemiparesis, hemisensory loss, and Aphasia


What area does the Posterior Cerebral artery supply?

Midbrain, thalamus, occipital lobe, and inferior surface of temporal lobe. Disruption causes homonymous hemianopia


Discus the branches of the MCA and the consequences of occlusion

They supply the internal capsule, putamen, and globus pallidus. Disruption may cause hemiplegia