Anticonvulsants Flashcards Preview

Neurology > Anticonvulsants > Flashcards

Flashcards in Anticonvulsants Deck (22):
1

What are the four mechanisms of Anticonvulsants?

1. Enhance sodium channel inhibition
2. Inhibit calcium channels
3. Enhance GABA inhibition
4. Inhibit glutamate receptors

2

Which drugs inhibit sodium channels?

Phenytoin, carbamazepine and lamotrigine

3

Which drugs inhibit calcium channels?

Ethosuximide, valproic acid, gabapentin, pregabalin

4

Which drugs enhance GABA ?

Benzodiazepines, barbiturates

5

What is the MOA of Phenytoin?

Prolongs the inactivation state of voltage gated sodium channels.

6

What are 2 pharmacokinectic properties of phenytoin?

1. Induces CYP3A4
2. 90% bound to albumin

7

What are the side effects of phenytoin?

1. Fatigue
2. Dizziness
3. Diplopia
4. Cognitive impairment

8

What is the MOA for Carbamazepine?

1. Blocks reactivation of voltage gated sodium channels.
2. Blocks NE reuptake

9

What are the side effects of carbamazepine?

1. Dizziness
2. Ataxia
3. Nystagmus

10

Which drugs side effect can cause Steven-Johnson syndrome?

Lamotrigine

11

What are the MOAs of Valproate?

1. Inhibits voltage gated sodium channels
2. Inhibits T-type calcium channels
3. May increase GABA synthesis and decrease degradation.

12

What are the side effects of Valproate?

1. Tremor
2. Hair loss
3. Thrombocytopenia

13

What is the MOA of Ethosuximide?

Inhibits T-type calcium channels in thalamic neurons.

14

What population is Ethosuximide used for?

Absence seizures in children

15

What is the MOA of Zonisamide?

Inhibits T-type Calcium channels and prolongs the inactivation of sodium channels.

16

What is the side effect of Zonisamide?

Difficulty concentrating and renal stones.

17

Discuss Zabapentin

GABA analog that may interac with Alpha-2-Delta subuni of L type voltage-sensitive calcium channels. Unchanged in urine

18

What are the MOAs for Topimarate?

1. Poteniates GABA response
2. Decreases glutamate receptor activity
3. Blocks voltage gated sodium channels

19

What is the main side effect of topimarate?

Weight loss

20

Which drugs have no effect of hepatic enzymes?

1. Ethosuximide
2. Gabapentin
3. Levatirectam
4. Pregabalin

21

Which drugs induce CYP450 enzymes?

1. Carbamazepine
2. Phenobarbital
3. Phenytoin

22

Which drugs inhibit P450 enzymes?

Topimarate, Valproate