Opioid Pharmacology Part 2 Flashcards Preview

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Flashcards in Opioid Pharmacology Part 2 Deck (15)
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1
Q

What are the CV effects of Morphine?

A
  1. Hypotension
  2. Vasodilation
  3. Decreased mycardial oxygen demand
2
Q

What are the GI effects of Morphine?

A
  1. Constipation

2. Increased biliary sphincter tone and pressure

3
Q

What are other effects of Morphine?

A
  1. Inhibition of LH release
  2. Stimulation of ADH and prolactin
  3. NK cell suppression
  4. Increased ICP
4
Q

What are the hallmarks of Opiate overdose?

A
  1. Coma
  2. Respiratory depression
  3. Miosis
5
Q

How is Opiate overdose treated?

A

Naloxone; Opioid receptor competitive antagonist

6
Q

What are some contraindications of opioids?

A

Head injuries, Seizure disorders, Alcohol intoxication

7
Q

How is opioid withdrawal induced?

A

Drug is stopped abruptly or antagonist is administered.

8
Q

What are the signs of opioid withdrawal??

A
  1. Diarrhea
  2. Vomiting
  3. Chills and Fever
9
Q

What is the Time course of withdrawal symptoms for Morphine?

A

Onset at 8-12 hours; Peak at 36-72 hours

10
Q

What is the time course of withdrawal sypmtoms of Meperidine?

A

Onset at 3 hours; Peak at 8-12 hours

11
Q

What is the time course of withdrawal symptoms of Methadone?

A

Onset at 24-48 hours

12
Q

Describe the PK of Morphine

A
  1. High first pass effect

2. Peak effect 1 hour after injection, lasts 3-4 hours.

13
Q

Describe Heroin in relation to Morphine

A

Three times as potent; Faster onset

14
Q

Describe Codeine in relation to Morphine

A

1/10th as potent as Morphine; Used as antitussive

15
Q

Which patients will not be affected by codeine?

A

Deficient in CYP2D6