Opioid Pharmacology Part 2 Flashcards Preview

Neurology > Opioid Pharmacology Part 2 > Flashcards

Flashcards in Opioid Pharmacology Part 2 Deck (15):
1

What are the CV effects of Morphine?

1. Hypotension
2. Vasodilation
3. Decreased mycardial oxygen demand

2

What are the GI effects of Morphine?

1. Constipation
2. Increased biliary sphincter tone and pressure

3

What are other effects of Morphine?

1. Inhibition of LH release
2. Stimulation of ADH and prolactin
3. NK cell suppression
4. Increased ICP

4

What are the hallmarks of Opiate overdose?

1. Coma
2. Respiratory depression
3. Miosis

5

How is Opiate overdose treated?

Naloxone; Opioid receptor competitive antagonist

6

What are some contraindications of opioids?

Head injuries, Seizure disorders, Alcohol intoxication

7

How is opioid withdrawal induced?

Drug is stopped abruptly or antagonist is administered.

8

What are the signs of opioid withdrawal??

1. Diarrhea
2. Vomiting
3. Chills and Fever

9

What is the Time course of withdrawal symptoms for Morphine?

Onset at 8-12 hours; Peak at 36-72 hours

10

What is the time course of withdrawal sypmtoms of Meperidine?

Onset at 3 hours; Peak at 8-12 hours

11

What is the time course of withdrawal symptoms of Methadone?

Onset at 24-48 hours

12

Describe the PK of Morphine

1. High first pass effect
2. Peak effect 1 hour after injection, lasts 3-4 hours.

13

Describe Heroin in relation to Morphine

Three times as potent; Faster onset

14

Describe Codeine in relation to Morphine

1/10th as potent as Morphine; Used as antitussive

15

Which patients will not be affected by codeine?

Deficient in CYP2D6