Flashcards in Opioid Pharmacology Part 2 Deck (15):
What are the CV effects of Morphine?
3. Decreased mycardial oxygen demand
What are the GI effects of Morphine?
2. Increased biliary sphincter tone and pressure
What are other effects of Morphine?
1. Inhibition of LH release
2. Stimulation of ADH and prolactin
3. NK cell suppression
4. Increased ICP
What are the hallmarks of Opiate overdose?
2. Respiratory depression
How is Opiate overdose treated?
Naloxone; Opioid receptor competitive antagonist
What are some contraindications of opioids?
Head injuries, Seizure disorders, Alcohol intoxication
How is opioid withdrawal induced?
Drug is stopped abruptly or antagonist is administered.
What are the signs of opioid withdrawal??
3. Chills and Fever
What is the Time course of withdrawal symptoms for Morphine?
Onset at 8-12 hours; Peak at 36-72 hours
What is the time course of withdrawal sypmtoms of Meperidine?
Onset at 3 hours; Peak at 8-12 hours
What is the time course of withdrawal symptoms of Methadone?
Onset at 24-48 hours
Describe the PK of Morphine
1. High first pass effect
2. Peak effect 1 hour after injection, lasts 3-4 hours.
Describe Heroin in relation to Morphine
Three times as potent; Faster onset
Describe Codeine in relation to Morphine
1/10th as potent as Morphine; Used as antitussive