Opioid Pharmacology Part 3 Flashcards Preview

Neurology > Opioid Pharmacology Part 3 > Flashcards

Flashcards in Opioid Pharmacology Part 3 Deck (15):
1

Discuss Meperidine

1. 1/10th potency of morphine
2. Short duration 2-4 hrs
3. Mydriasis at toxic doses

2

Discuss Methadone

1. Slow onset and long duration
2. Tolerance develops slowly
3. Less sedative

3

Discuss Oxycodone

Used in combination with acetaminophen or aspirin

4

Discuss Fentanyl

1. 100 times more potent than morphine

5

Discuss Dextromethorphan

1. OTC antitussive
2. NDMA recepter antagonists at high doses

6

Discuss Tramadol

1. Synthetic codeine analog
2. Inihibits uptake of NE and Serotonin

7

Discuss Nalbuphine

Antagonist at mu, agonist at kappa

8

Discuss Butorphanol

Partial agonist at mu, agonist at kappa

9

Discuss Buprenorphrine

1. Partial mu agonist
2. Helps with withdrawal in low doses.

10

What are the opioid receptor antagonists?

Naloxone and Naltrexone

11

Discuss Naloxone

1. Blocks agonist effects of morphine.
2. DOA is 2 hrs

12

Discuss Naltrexone

Longer DOA than Naloxone. Used to prevent relapse in chronic alcoholics

13

Discuss opioid interactions with sedatives

Increased respiratory depression.

14

Discuss opioid interactions with phenothiazines

Increased sedation and atropine like effects; A1 adrenergic antagonist effects.

15

Discuss opioid interactions with MAO inhibitors

Hyperpyrexia, coma