Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BB LEC > Blood Group RH > Flashcards

Blood Group RH Flashcards

1
Q

Who Described a hemolytic transfusion reaction in an obstetrical patient

A

Levine and Stetson

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

T/F
Rh product is a glycosylated protein

A

False. Nonglycosylated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Postulated that the antigens from the system were produced by 3 closely linked sets of alleles. Each gene was responsible for producing a product (Ag) on the red cell surface.

A

Fisher and Race

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

possessing half the normal number of chromosome found on the cell

A

Haplotype

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Most immunogenic Rh antigen

A

D antigen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Believed that the gene responsible for defining Rh actually produced an agglutinogen that contains a series of blood factors.

A

Wiener

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

A substance that stimulates the production of agglutinin, thereby acting as an antigen.

A

Agglutinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

represent the presence of a single haplotype composed of three different antigens.

A

Wiener

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Proposed a system that assigns a number to each antigen of Rh system in order of its discovery or recognized relationship to the Rh system in the 1960s.

A

Rosenfield

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

They adapted a six-digit number for each blood group.

A

ISBT (International Society of Blood transfusion)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

They adapted a six-digit number for each blood group.
First three numbers =???
Remaining three numbers =???

A

-system
-antigenic specificity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Half-life of Rh Abs in serum/plasma:

A

1 year

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

These are IgG that react optimally at 37oC or following the addition of antiglobulin reagent.

A

Rh Abs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Red cell destruction due to Rh Abs is primarily extravascular. This type of hemolysis classically characterizes a

A

Delayed Hemolytic Transfusion Reaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Highly immunogenic

A

Rh Ag

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Only antigen that undergoes routine testing. And it is most potent

A

D Ag

17
Q

Arrange highly to rarely immunogenic of Rh Ag: D C E c e

A

D c E C e

18
Q

Tippett correctly proposed two Rh genes which are the:

Located in what chromosomes?

A

RHD AND RHCE

Chromosomes 1

19
Q

This codes for the presence or absences of RHD proteins

A

RHD

20
Q

Codes for either RhCe, Rhce, RhcE, RhCE proteins

A

RHCE

21
Q

How many exons does RHD AND RHCE genes have

A

10 exons

22
Q

RHAG resides in what chromosomes

A

Chromosomes 6

23
Q

present for successful expression of the Rh antigens.

A

Coexpressor

24
Q

Refers to red cells carrying the weaker D antigens

A

Du type

25
Q

Inheritance of D genes that code for a weakened expression of the D antige

A

Genetic weak D

26
Q

A position effect or gene interaction effect

A

C Trans

27
Q

location of two or more genes on the same chromosome of a homologous pair.

A

Cis

28
Q

Happens when one or more parts of the D antigen are missing.

A

D mosaic (Partial D)

29
Q

Who Postulated that the complete D (RH0) antigen has four parts: RhA, RhB, RhC, RhD

A

Wiener and Unger

30
Q

The weakest D variant

A

Rh del

31
Q

red blood cells possess an extremely low number of D antigen sites that most reagent anti-D are unable to detect. They often appear as Rh-.

A

Rh del

32
Q

Adsorb and Elute anti-D, appear by

A

Flow cytometry

33
Q

Written as —/—

A

Rh null

34
Q

Weakened expression of all Rh antigen

A

Rhmod

35
Q

this phenotype in written
format, parentheses are used as in (D), (C), and (e) to indicate the weakened expression of the given antigen.

A

Rhmod

36
Q

This reagent is used To confirm that washing has been adequate
and the antiglobulin reagent is reactive.

A

Coomb’s cells

37
Q

A group O Rh positive donor’s sample is mixed with 1:10 dilution of reagent anti-D and allowed to incubate.

A

Control cell

BB LEC (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions