Kell, Kidd, Duffy

Question 1

This was the first blood group system discovered after the introduction of antiglobulin testing.

Answer 1

KELL BLOOD GROUP

Question 2

MODIFIED T/F: Kell blood group antigens are found on platelets or on lymphocytes, granulocytes, or monocytes..

Answer 2

FALSE. RBCs only

Question 3

If Kell antigens are absent on WBCs, they are associated with?

Answer 3

CHRONIC GRANULOMATOUS DISEASE

Question 4

If Kell antigens are found on WBCs, they will remain?

Answer 4

Unconverted

Question 5

Excluding the ABO blood group system, what is the second most immunogenic antigen after the Rh (D) Antigen?

Answer 5

Kell Antigen

Question 6

Kell glycoprotein is a member of the?

Answer 6

neprilysin (M13) family of zinc endopeptidases.

Question 7

Detected on fetal RBCs as early as 10 weeks and Well developed at birth

Answer 7

K Antigen

Question 8

Despite its lower quantity, it is very
immunogenic.

Answer 8

K Antigen

Question 9

Jsa is also known as

Answer 9

Sutter

Question 10

Kpa is also known as

Answer 10

Penny

Question 11

k is also known as

Answer 11

Cellano

Question 12

Kpb is also known as

Answer 12

Rautenberg

Question 13

Jsb is also known as

Answer 13

Matthews

Question 14

Class is also known as

Answer 14

KL

Question 15

Peltz is also known as

Answer 15

Ku

Question 16

Williams is also known as

Answer 16

Kw

Question 17

Detected on fetal RBCs at 7 weeks

Answer 17

k antigen

Question 18

Absent of this results Mcleod Syndrome

Answer 18

Kx antigen

Question 19

Kell antibodies associated with severe HTS AND HDFN? T or F

Answer 19

True

Question 20

Anti K reacts more weakly in test using what reagents

Answer 20

LISS

Question 21

Present on all RBCs except those of rare McLeod phenotype

Answer 21

Kx Antigen

Question 22

Kx antigen increases in what phenotypes

Answer 22

Ko and Kmod phenotypes

Question 23

RBCs lack expression of all Kell antigens and No membrane abnormality

Answer 23

Knull, Ko Phenotype

Question 24

Immunized individuals with the K0 phenotype typically make an antibody called?

Answer 24

Anti-Kun(K5)

Question 25

X-linked disorder associated with the different WBCs and macrophages.

Answer 25

CHRONIC GRANULOMATOUS DISEASE

Question 26

In this disorder, the normal functional properties of phagocytic white blood cells are impaired. The phagocytes are able to engulf but not kill microorganisms. Because of this functional defect, patients possess an increased susceptibility to infections.

Answer 26

CHRONIC GRANULOMATOUS DISEASE

Question 27

Characterized by the inability of phagocytes to make NADH oxidase, an enzyme important in generating H2O2, which is used to kill ingested bacteria.

Answer 27

CGD

Question 28

Synthenic to the Rh blood group

Answer 28

Duffy Blood groups system

Question 29

Fy(a–b–) RBCs resist infection in vitro by the?

Answer 29

P. Knowlesi and P. Vivax

Question 30

First described form the serum of a Fy(a–b–) white Australian female

Answer 30

Fy3

Question 31

Fyb allele encodes what antigens

Answer 31

Fyb, Fy3, Fy5, Fy6 antigens

Question 32

Simple and straightforward blood group system

Answer 32

Kidd

Question 33

Encodes Jka and Jk3 antigens

Answer 33

JKA Alleles

Question 34

Encodes Jkb and Jk3 antigens

Answer 34

JKB Allele

Question 35

Silent allele in Kidd Blood group system, procduce neither Jka Jkb

Answer 35

Jk allele

Question 36

A phenomenon whereby an antibody reacts more strongly with a red cell carrying a double dose than with a red cell carrying a single dose

Answer 36

Dosage Effect

Question 37

What blood group system causes severe HDFN

Answer 37

Rh

Question 38

What blood group system causes immediate HTRS

Answer 38

ABO

Question 39

What blood group system causes delayed HTRs

Answer 39

Kidd

Question 40

Important anthropological markers for African blacks

Answer 40

Fy (a-b-)

Question 41

This resist lysis in 2 M urea and occurs mainly in Mongoloids

Answer 41

Jk (a-b-)

Question 42

The expression of this is weak in McLeod phenotype cells

Answer 42

Kell Antigens

Question 43

N terminal domain is located in?

Answer 43

Intracellular

Question 44

This is the large external that is highly folded by disulfide linkages

Answer 44

C Terminal Domain

Question 45

This antibodies is made in response to antigen exposure through pregnancy and transfusion

Answer 45

Anti K

Question 46

Increase in Kx antigen indicates?

Answer 46

Ko, Kmod phenotype

Question 47

This antibodies is most often detected through unexpected incompatible crossmatches or cases of HDFN

Answer 47

Kpa, Jsa and other low frequency kell antigens

Question 48

This Expressed at least 99% of the total population regardless of race.

Answer 48

High frequency kell antigens

Question 49

This is important in the expression of Kx and Kell antigens

Answer 49

Xk Proteins

Question 50

What phenotype is associated with reticulocytosis, bilirubinemia, splenomegaly and reduced serum haptoglobin levels,

Answer 50

McLeod Phenotype

Question 51

What enzyme is important in generating H2O2 which is used to kill ingested bacteria

Answer 51

NADH (Nicotinamide Adenine Dinucleotide Hydrogen)

Question 52

It means that it is located on the same chromosome

Answer 52

Synthetic

Question 53

How does Fyb (Fy2) found?

Answer 53

In the serum of a woman who had three pregnancies

Question 54

What allele cannot express duffy antigen

Answer 54

FY allele

Question 55

This does not produce distinct antigen but rather it can inherit weak form of Fyb

Answer 55

Fyx

Question 56

Detected on fetal RBCs as early as 11 weeks

Answer 56

Jka

Question 57

In kidd Detected on fetal RBCs as early as 7 weeks

Answer 57

Jkb

Question 58

What are the two primary characteristics of Kidd

Answer 58

Delayed HTRS, and Extravascular hemolytic transfusion