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Physiology > Blood Physiology > Flashcards

Blood Physiology Flashcards

(61 cards)

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0
Q

Which complement is an anaphylatoxin (induces inflammation)?

A

C3a, C4a, C5a

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1
Q

Which complement is responsible for opsonization?

A

C3b

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2
Q

Which complement is chemotactic to WBC?

A

C5a

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3
Q

Which complement is part of the Membrane Attack Complex?

A

C3b - C9

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4
Q

Process of forming blood cells in the bone marrow

A

Hematopoiesis

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5
Q

Site of blood cell formation beginning from 3rd wk AOG

A

Yolk sac/aortic gonad mesonephros (AGM) region

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6
Q

Site of blood cell formation from 3rd month AOG to birth

A

Liver (with minor contributions from spleen, LN)

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7
Q

Only source of blood cells postnatally; begins at 4th month AOG

A

Bone marrow

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8
Q

All bone marrow are active

A

Birth to puberty

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9
Q

Only bone marrow of vertebra, ribs, sternum, skull, pelvis, proximal epiphyseal region of humerus active

A

Age 20

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10
Q

Post-embryonic extramedullay hematopoiesis in fullterm infant

A

Always abnormal

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11
Q

How many oxygen molecules can 1 hemoglobin molecule bind?

A

4 O2 molecules

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12
Q

Hormone stimulating RBC production

A

Erythropoietin

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13
Q

Main stimulus for EPO production

A

Hypoxia

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14
Q

Effect of EPO will manifest after this many days

A

5 days

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15
Q

Last RBC stage with a nucleus

A

Orthochromatic erythroblast

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16
Q

RBC stage released to the blood

A

Reticulocytes

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17
Q

Tlme to convert reticulocytes to mature RBC

A

1-2 days

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18
Q

Characteristics of mature RBC

A

NO nucleus, mitochondria nor ER

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19
Q

Lifespan of adult RBC

A

120 days

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20
Q

Lifespan of fetal RBC

A

90 days

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21
Q

Intravascular destruction of old or damaged RBC occurs here

A

Spleen

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22
Q

Extravascular destruction of RBC is due to

A

Macrophages

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23
Q

Fate of heme in destroyed RBC

A

Bilirubin

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24
Nutrient essential for DNA synthesis
Folic acid, Vit B12
25
Megaloblastic anemia + neural deficits
Vit B12 deficiency
26
Megaloblastic anemia + neural tube disorders
Folic acid deficiency
27
Needed to absorb VIt B12
Intrinsic factor
28
Sources of Vit B12
Meat
29
Sources of folic acid
Leafy vegetables, cauliflower, brocolli
30
Lifespan of granulocytes
4-8 hrs in the blood, 4-5 days in tissues (shortened during infection)
31
Lifespan of monocytes
10-20 hrs in the blood, for several months in the tissues
32
Lifespan of lymphocytes
Weeks to months
33
Lifespan of platelets
7-10 days
34
Movement of neutrophils & macrophages towards a chemical signal
Chemotaxis
35
Movement out of the circulatory system & into the site of injury
Diapedesis
36
How many oxygen molecules can 1 hemoglobin molecule bind?
4 O2 molecules
37
Hormone stimulating RBC production
Erythropoietin
38
Main stimulus for EPO production
Hypoxia
39
Effect of EPO will manifest after this many days
5 days
40
Last RBC stage with a nucleus
Orthochromatic erythroblast
41
RBC stage released to the blood
Reticulocytes
42
Tlme to convert reticulocytes to mature RBC
1-2 days
43
Characteristics of mature RBC
NO nucleus, mitochondria nor ER
44
Lifespan of adult RBC
120 days
45
Lifespan of fetal RBC
90 days
46
Intravascular destruction of old or damaged RBC occurs here
Spleen
47
Extravascular destruction of RBC is due to
Macrophages
48
Fate of heme in destroyed RBC
Bilirubin
49
Nutrient essential for DNA synthesis
Folic acid, Vit B12
50
Megaloblastic anemia + neural deficits
Vit B12 deficiency
51
Megaloblastic anemia + neural tube disorders
Folic acid deficiency
52
Needed to absorb VIt B12
Intrinsic factor
53
Sources of Vit B12
Meat
54
Sources of folic acid
Leafy vegetables, cauliflower, brocolli
55
Lifespan of granulocytes
4-8 hrs in the blood, 4-5 days in tissues (shortened during infection)
56
Lifespan of monocytes
10-20 hrs in the blood, for several months in the tissues
57
Lifespan of lymphocytes
Weeks to months
58
Lifespan of platelets
7-10 days
59
Movement of neutrophils & macrophages towards a chemical signal
Chemotaxis
60
Movement out of the circulatory system & into the site of injury
Diapedesis

Physiology (11 decks)

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