Blood Physiology Flashcards Preview

Physiology > Blood Physiology > Flashcards

Flashcards in Blood Physiology Deck (61):
0

Which complement is responsible for opsonization?

C3b

1

Which complement is an anaphylatoxin (induces inflammation)?

C3a, C4a, C5a

2

Which complement is chemotactic to WBC?

C5a

3

Which complement is part of the Membrane Attack Complex?

C3b - C9

4

Process of forming blood cells in the bone marrow

Hematopoiesis

5

Site of blood cell formation beginning from 3rd wk AOG

Yolk sac/aortic gonad mesonephros (AGM) region

6

Site of blood cell formation from 3rd month AOG to birth

Liver (with minor contributions from spleen, LN)

7

Only source of blood cells postnatally; begins at 4th month AOG

Bone marrow

8

All bone marrow are active

Birth to puberty

9

Only bone marrow of vertebra, ribs, sternum, skull, pelvis, proximal epiphyseal region of humerus active

Age 20

10

Post-embryonic extramedullay hematopoiesis in fullterm infant

Always abnormal

11

How many oxygen molecules can 1 hemoglobin molecule bind?

4 O2 molecules

12

Hormone stimulating RBC production

Erythropoietin

13

Main stimulus for EPO production

Hypoxia

14

Effect of EPO will manifest after this many days

5 days

15

Last RBC stage with a nucleus

Orthochromatic erythroblast

16

RBC stage released to the blood

Reticulocytes

17

Tlme to convert reticulocytes to mature RBC

1-2 days

18

Characteristics of mature RBC

NO nucleus, mitochondria nor ER

19

Lifespan of adult RBC

120 days

20

Lifespan of fetal RBC

90 days

21

Intravascular destruction of old or damaged RBC occurs here

Spleen

22

Extravascular destruction of RBC is due to

Macrophages

23

Fate of heme in destroyed RBC

Bilirubin

24

Nutrient essential for DNA synthesis

Folic acid, Vit B12

25

Megaloblastic anemia + neural deficits

Vit B12 deficiency

26

Megaloblastic anemia + neural tube disorders

Folic acid deficiency

27

Needed to absorb VIt B12

Intrinsic factor

28

Sources of Vit B12

Meat

29

Sources of folic acid

Leafy vegetables, cauliflower, brocolli

30

Lifespan of granulocytes

4-8 hrs in the blood, 4-5 days in tissues (shortened during infection)

31

Lifespan of monocytes

10-20 hrs in the blood, for several months in the tissues

32

Lifespan of lymphocytes

Weeks to months

33

Lifespan of platelets

7-10 days

34

Movement of neutrophils & macrophages towards a chemical signal

Chemotaxis

35

Movement out of the circulatory system & into the site of injury

Diapedesis

36

How many oxygen molecules can 1 hemoglobin molecule bind?

4 O2 molecules

37

Hormone stimulating RBC production

Erythropoietin

38

Main stimulus for EPO production

Hypoxia

39

Effect of EPO will manifest after this many days

5 days

40

Last RBC stage with a nucleus

Orthochromatic erythroblast

41

RBC stage released to the blood

Reticulocytes

42

Tlme to convert reticulocytes to mature RBC

1-2 days

43

Characteristics of mature RBC

NO nucleus, mitochondria nor ER

44

Lifespan of adult RBC

120 days

45

Lifespan of fetal RBC

90 days

46

Intravascular destruction of old or damaged RBC occurs here

Spleen

47

Extravascular destruction of RBC is due to

Macrophages

48

Fate of heme in destroyed RBC

Bilirubin

49

Nutrient essential for DNA synthesis

Folic acid, Vit B12

50

Megaloblastic anemia + neural deficits

Vit B12 deficiency

51

Megaloblastic anemia + neural tube disorders

Folic acid deficiency

52

Needed to absorb VIt B12

Intrinsic factor

53

Sources of Vit B12

Meat

54

Sources of folic acid

Leafy vegetables, cauliflower, brocolli

55

Lifespan of granulocytes

4-8 hrs in the blood, 4-5 days in tissues (shortened during infection)

56

Lifespan of monocytes

10-20 hrs in the blood, for several months in the tissues

57

Lifespan of lymphocytes

Weeks to months

58

Lifespan of platelets

7-10 days

59

Movement of neutrophils & macrophages towards a chemical signal

Chemotaxis

60

Movement out of the circulatory system & into the site of injury

Diapedesis