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Flashcards in Respiratory Physiology Deck (56):
0

Cannot be measured directly by spirometry

RV, TLC, FRC

1

Amount of air inspired & expired during quiet breathing

TV

2

Maintains oxygenation in between breaths

RV

3

Equilibrium/resting volume of the lung

FRC

4

Marker for lung function

FRC

5

What happens to the FEV1 & FVC in patients w/ obstructuve & restrictive lung diseases

Decrease

6

What is the FEV1/PVC ratio of a healthy person

0.8

7

What happens to the FEV1/PVC ratio in a patient with obstructive lung diseases?

Decreased

8

What happens to the FEV1/PVC ratio in a patient with restrictive lung diseases?

Normal or increased

9

Cells that produce surfactant

Type 2 pneumocytes

10

Main component of surfactant

Water

11

Active component of surfactant

Dipalmitoyl-phosphatidylcholine/Lecithin

12

Mechanism for DPPC reducing surface tension

Amphipathic nature (hydrophobic & hydrophilic nature)

13

Effect of surfactant on lung compliance

Increase

14

Start of surfactant production

24th week AOG

15

Maturation of surfactant

35th wk AOG

16

Test for surfactant

Amniotic L:S ratio

17

What is the only form of gas thy contributes to partial pressure

Dissolved gas

18

What is the only gas in inspired air found exclusively as dissolved gas

Nitrogen

19

O2 transport at rest

Perfusion-limited

20

O2 transport during exercise & diseases states

Diffusion-limited

21

O2 transport in high altitude

Slow

22

Equilibration of O2 at sea level

1/3 length of pulmonary capillary

23

Equilibration of O2 at high altitude

2/3 length of pulmonary capillary

24

Percentage of dissolved O2

2%

25

Percentage of O2 bound to Hb

98%

26

Hb with attached O2

Oxyhemoglobin

27

Hb without attached O2

Deoxyhemoglobin

28

Hb with Fe3, does not bind O2

Methemoglobin

29

Max O2 binding w/ Hb

O2 binding capacity

30

% of blood that gives up its O2 as it passes through the tissues

Utilization coefficient

31

90% of CO2 in the blood

HCO3

32

5% of CO2 in blood

Dissolved CO2

33

3% of CO2 in blood

CarbaminoHb

34

Cl-HCO3 exchange in the RBC

Chloride shift (using band 3 protein)

35

O2 affecting affinity of CO2/H to Hb

Haldane effect

36

CO2/H affecting affinity of O2 to Hb

Bohr effect

37

Pulmonary pressure & resistance

< Systemic circulation

38

Pulmonary circulation: blood flow

= systemic circulation

39

Pulmonary blood flow: supine

Same through the entire lung

40

Pulmonary blood flow:

Lowest at the apex, highest at the base

41

Effect of hypoxia (low PAO2) on pulmonary arterioles

Vasoconstriction

42

Lung vasoactive substances

TXA2, PGI2

43

Causes bronchoconstriction

Leukotrines

44

What lung zones do we see in the Apex of the lungs?

2,3

45

What lung zone do we see in the base of the lungs?

3

46

What lung zone do we see in a supine position or during exercise throughout the lungs?

3

47

What lung zones do we see in cases of pulmonary hemorrhage or positive pressure ventilation

1

48

Site of highest ventilation

Base of the lungs

49

Site of highest perfusion (Q)

Base of the lungs

50

Site of highest V/Q ratio

Apex of the lungs

51

Perfusion of lungs with no ventilation (V/Q = zero)

Shunt

52

Inspiratory center; control basic rhythm, normal inspiration

Dorsal raspi group

53

Overdrive mechanism during exercise, for forced inspiration & expiration

Ventral respi geoup

54

Found in the lower pons; for prolonged inspiratory gas; decreases RR apneustic

Apneustic center

55

Found in the upper pons; limits time for inspiration w/c increases RR

Pneumotaxic center