Flashcards in Bone Deck (17):
What type of mutation is achondroplasia?
-gain of function AD mutation in fibroblast growth factor receptor 3
-defect in synthesis of collagen 1
-erlenmeyer flask shaped deformity
-tx: hematopoetic stem cell transplantation
-AD and AR types
-myelophistic process causes bone marrow to be depleted leading to anemia
-narrowing of cranial foramina
-excessive bone resorption followed by disorganized bone replacement
-may be due to infection with paramyxovirus and mutations of SQSTM1
-3 stages: osteolytic stage, mixed, and osteosclerotic stage
-inc. alk phos and hydroxyproline
-**mosaic pattern of lamellar bone**
-Beethoven may have had this (deaf after 40) (or neurosyphilis)
What part of the bone does hematogenous osteomyelitis typically affect?
Sunburst sign on X Ray is indicative of:
A type of bone cancer arising within the marrow cavity.
Onion skin layering of new bone.
Diaphysis of long bones most affected.
Small, round, blue cells may form Homer Wright pseudo rosettes.
T(11;22) mutation in EWS/FLI1 common.
Distal interphalangeal joint swelling due to osteoarthritis.
Proximal interphalangeal joint nodes due to osteoarthritis.
HLA associations with RA?
HLA DR4 and HLA DR1
HLA associated with spondyloarthopathies?
Triad of reactive arthritis.
Can't see, can't pee, can't climb a tree. I.e. Conjunctivitis, urethritis, and arthritis. Often follow venereal dz or dysentery.
-Weakly birifringent rhomboid shaped crystals made of calcium pyrophosphate
-knee joint is commonly involved
When do you see a dry tap?
-hairy cell leukemia
Causes of aseptic necrosis of femoral head.
-long term corticosteroids
-may see bilateral hip pain
-layer of fibrovascular tissue or granulation tissue
-inflammation/proliferation of synovium leads to pannus and destruction of bone and cartilage
-associated with Rheumatoid Arthritis