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Flashcards in Derm Deck (19):
1

Actinic Keratosis

-small, erythematous epidermal lesions from chronic sun exposure
-a small percent progress to invasive squamous cell carcinoma

2

Erythema Multiform

Cell mediated inflammatory disorder of erythematous papules that develop into target lesions. Commonly associated with herpes simplex infection.

3

Stevens Johnson Syndrome

Erythematous macules with necrosis and skin sloughing. Systemic signs common (fever). Associated with medications.

4

Lesser Trelat

-many sudden seborrheic keratosis
-sign of internal malignancy

5

Dermatomyositis

-grotton papules on hand joints
-heliotrope rash (periorbital rash)
-anti-Jo-1 is specific
-proximal muscle weakness, elevated muscle enzymes
Associated with underlying malignancy.

6

Pemphigus Vulgaris

-flaccid bullae
-erosion of skin and mucous membrane (mouth)
-antibodies against desmosomes, desmogleins 1 and 3
-intracellular IgG and C3 deposits

7

Bullous Pemphigoid

-antibodies against hemidesmosomes
-tense blisters

8

Xanthelasmas

-type of xanthoma on eye lid
-yellow macule/papule
-accumulations of macrophages containing cholesterol and triglycerides
-associated with hyperlipidemia (usually due to LDL receptor abnormality)

9

Spongiosis

-characterizes acute eczematous dermatitis
-may be due to allergic reaction on skin

10

Albinism

Melanocytes that do not produce melanin.

11

Vitiligo

Loss of epidermal melanocytes.

12

Porphyria Cutania Tarda

Skin fragility and blistering rash in sun exposed areas.

13

Holocrine Gland

Releases entire cell contents via cells lysis. Ex. Sebaceous gland

14

Apocrine Gland

Releases membrane bound vesicles containing contents. Ex. Mammary gland

15

Merocrine Gland

Cells secrete via exocytosis. Ex. Salavary gland, eccrine sweat gland, apocrine sweat gland

16

Osler-Weber-Rendu Syndrome (Hereditary Hemorrhagic Telangiectasia)

-AD
-telangiectasias of skin, mucous membranes of oral mucosa and resp. tract, GI, and urinary tract
-rupture may cause epistaxis, GI bleeding, or hematuria

17

Dermatitis Herpetaformis

-chronic blistering skin infection related to celiac disease

18

MOA of Tretinoin

-activation of nuclear gene transcription
-teratogen
-reduces sebum
-used for wrinkles and acne

19

Post Herpetic Neuralgia

-pain related to sensitization of afferent nerves in the dorsal horn after shingles outbreak