Flashcards in Derm Deck (19):
-small, erythematous epidermal lesions from chronic sun exposure
-a small percent progress to invasive squamous cell carcinoma
Cell mediated inflammatory disorder of erythematous papules that develop into target lesions. Commonly associated with herpes simplex infection.
Stevens Johnson Syndrome
Erythematous macules with necrosis and skin sloughing. Systemic signs common (fever). Associated with medications.
-many sudden seborrheic keratosis
-sign of internal malignancy
-grotton papules on hand joints
-heliotrope rash (periorbital rash)
-anti-Jo-1 is specific
-proximal muscle weakness, elevated muscle enzymes
Associated with underlying malignancy.
-erosion of skin and mucous membrane (mouth)
-antibodies against desmosomes, desmogleins 1 and 3
-intracellular IgG and C3 deposits
-antibodies against hemidesmosomes
-type of xanthoma on eye lid
-accumulations of macrophages containing cholesterol and triglycerides
-associated with hyperlipidemia (usually due to LDL receptor abnormality)
-characterizes acute eczematous dermatitis
-may be due to allergic reaction on skin
Melanocytes that do not produce melanin.
Loss of epidermal melanocytes.
Porphyria Cutania Tarda
Skin fragility and blistering rash in sun exposed areas.
Releases entire cell contents via cells lysis. Ex. Sebaceous gland
Releases membrane bound vesicles containing contents. Ex. Mammary gland
Cells secrete via exocytosis. Ex. Salavary gland, eccrine sweat gland, apocrine sweat gland
Osler-Weber-Rendu Syndrome (Hereditary Hemorrhagic Telangiectasia)
-telangiectasias of skin, mucous membranes of oral mucosa and resp. tract, GI, and urinary tract
-rupture may cause epistaxis, GI bleeding, or hematuria
-chronic blistering skin infection related to celiac disease
MOA of Tretinoin
-activation of nuclear gene transcription
-used for wrinkles and acne