Derm Flashcards
(19 cards)
Actinic Keratosis
- small, erythematous epidermal lesions from chronic sun exposure
- a small percent progress to invasive squamous cell carcinoma
Erythema Multiform
Cell mediated inflammatory disorder of erythematous papules that develop into target lesions. Commonly associated with herpes simplex infection.
Stevens Johnson Syndrome
Erythematous macules with necrosis and skin sloughing. Systemic signs common (fever). Associated with medications.
Lesser Trelat
- many sudden seborrheic keratosis
- sign of internal malignancy
Dermatomyositis
-grotton papules on hand joints
-heliotrope rash (periorbital rash)
-anti-Jo-1 is specific
-proximal muscle weakness, elevated muscle enzymes
Associated with underlying malignancy.
Pemphigus Vulgaris
- flaccid bullae
- erosion of skin and mucous membrane (mouth)
- antibodies against desmosomes, desmogleins 1 and 3
- intracellular IgG and C3 deposits
Bullous Pemphigoid
- antibodies against hemidesmosomes
- tense blisters
Xanthelasmas
- type of xanthoma on eye lid
- yellow macule/papule
- accumulations of macrophages containing cholesterol and triglycerides
- associated with hyperlipidemia (usually due to LDL receptor abnormality)
Spongiosis
- characterizes acute eczematous dermatitis
- may be due to allergic reaction on skin
Albinism
Melanocytes that do not produce melanin.
Vitiligo
Loss of epidermal melanocytes.
Porphyria Cutania Tarda
Skin fragility and blistering rash in sun exposed areas.
Holocrine Gland
Releases entire cell contents via cells lysis. Ex. Sebaceous gland
Apocrine Gland
Releases membrane bound vesicles containing contents. Ex. Mammary gland
Merocrine Gland
Cells secrete via exocytosis. Ex. Salavary gland, eccrine sweat gland, apocrine sweat gland
Osler-Weber-Rendu Syndrome (Hereditary Hemorrhagic Telangiectasia)
- AD
- telangiectasias of skin, mucous membranes of oral mucosa and resp. tract, GI, and urinary tract
- rupture may cause epistaxis, GI bleeding, or hematuria
Dermatitis Herpetaformis
-chronic blistering skin infection related to celiac disease
MOA of Tretinoin
- activation of nuclear gene transcription
- teratogen
- reduces sebum
- used for wrinkles and acne
Post Herpetic Neuralgia
-pain related to sensitization of afferent nerves in the dorsal horn after shingles outbreak
