Bone and Cartilage Pathology I Flashcards Preview

MSK Exam 1 Spring 2015 > Bone and Cartilage Pathology I > Flashcards

Flashcards in Bone and Cartilage Pathology I Deck (61):
1

osteoid

soft and squishy

2

osteoblast derived proteins

type I collagen

3

osteoblasts

lay down bone

mononuclear**

4

osteoblastic tumor

prostate pets
-lays down bone

5

osteoclasts

macrophage family

break down bone

multinucleated - 3-25 nuclei**

6

bone homeostasis

10% bone replace anually

7

peak bone mass

early in adulthood right after puberty

8

catabolic

break down bone

9

anabolic

lay down new bone

10

increased PTH

osteoclast activity

11

decreased PTH

osteoblast activity

12

RANK/RANK-L

interaction stimulates osteoclast formation

13

FGFR3

achrondoplasia

14

COL1A1 and COL1A2

osteogenesis imperfecta

15

HOXD13

bradydactylyl type D and E

16

common cause of dwarfism

achondroplasia

17

blue sclera

osteogenesis imperfecta

18

short broad terminal phalanges of first digits

bradydactyly

19

most common disease of growth plate

achondroplasia

20

why blue sclera

missing collagen type I
-see choroid of eye through sclera

21

brittle bone disease

osteogenesis imperfecta

22

deficiency in synthesis of collage type I

osteogenesis imperfecta

23

kids with lots of fractures

osteogenesis imperfecta

24

subtypes of OI

1 - decreased synthesis of pro-alpha1 chain
auto dominant

2 and 3 - don't survive

4 - compatible with life auto dominant
-short pro-alpha2

25

marble bone disease

osteopetrosis

26

albers schonberg disease

osteopetrosis

27

reduced bone resoprtion and skeletal sclerosis

osteopetrosis

missing osteoclasts

28

X-ray with thick femur

osteopetrosis

29

erlenmeyer flask deformity

osteopetrosis

30

osteopetrosis

deficient osteoclasts
-bulbous long bones
-compression of neural foramina

31

cannot hear

common problem with osteopetrosis

32

anemia, thrombocytopenia, leukopenia

replace marrow with crappy bone
-in osteopetrosis

get infections

33

auto recessive osteopetrosis

fracture, anemia, hydrocephaly - postpartum mortality

34

auto dominant osteopetrosis

detected adolescence or adulthood
-repeated fractures

may have CN deficits and anemia

35

dystoses

abnormalities in single bone or localized group of bone

arise from defects in migration and condensation of mesenchyme

absent, supernumary, or fused bones

36

dysplasia

global disorganization of bone and cartilage

37

mutation in CA2

osteopetrosis
renal tubular acidosis

38

osteopenia vs. osteoporosis

both decreased bone mass

osteoporosis - severe enough osteopenia that you get risk of fractures

39

infections and fractures

osteopetrosis

40

primary causes of osteoporosis

idiopathic
postmenopausal
senile

41

iatrogenic osteoporosis

over-tx of hyperthyroidism

42

most common forms of osteoporosis

senile and postmenopausal forms

43

histo normal bone decreased in quantity

osteoporosis

44

vertebral collapse

with osteoporosis

45

menopause changes

decreased estrogen
increased IL1, IL6 and TNF
increased RANK/RANKL
increased osteoclast activity

lead to osteoporosis

46

vertebral fractures, lumbar lordosis, kyphoscoliosis

osteoporosis

47

complication of osteoporosis

PE and pneumonia**

48

paget disease

osteitis deformans

increased but disordered and structurally unsound bone mass

osteoclast work over time - osteoblast can't keep up

49

stages of pagets

osteolytic - osteoclasts
osteosclerotis - osteoblasts
mixed - both

50

mosaic pattern of lamellar bone

sclerotic phase of paget disease

prominent cement lines

51

paget clinical

15% monostotic
85% polyostotic**

often involves axial skeleton and proximal femur

52

leontiasis ossea

lion face - caused by enlargement of craniofacial skeleton - in pagets

53

complication of paget

sarcoma

54

saber bone

pagets
-bowed bone

55

rickets

vit D deficiency in kids

56

osteomalacia

vit D deficiency in adults

57

string of beads

along ribs

with ricketic rosary

58

PTH effect

increases RANKL on osteoblasts
-activates osteoclasts

59

hyperparathyroidism

increased resorption of calcium by renal tubules
increased urinary excretion of phosphates
increased bone resorption - osteoclasts

60

most common cause hyperPTH

PTH adenoma
-often asymptomatic - hyperCa on screening

61

dissecting osteitis

with hyperPTH