Skin Pathology I Flashcards Preview

MSK Exam 1 Spring 2015 > Skin Pathology I > Flashcards

Flashcards in Skin Pathology I Deck (54):
1

skin function

protective covering - non-permeable
tactile interaction
body temp regulation
sexual attraction
immunity - APCs - langerhans epidermal dendritic cells

2

adnexa

pilar unit
eccrine unit
apocrine unit

3

two layers of dermis

papillary and reticular

4

layers of epidermis

stratum corneum
stratum lucidum
stratum granulosum
stratum spinosum
stratum basale

DEJ - dermal epidermal junction

papillary dermis
reticular dermis

5

horny layer

stratum corneum

6

apocrine glands

deep dermis at junction of reticular dermis and subQ tissue

more in inguinal, axilla, scalp

more eosinophilic cytoplasm

7

melanocytes

supplies pigment to squamous cells

8

desmosomes

intercellular bridges
-tight junctions

9

papillary dermis

finely woven type I collagen parallel to surface

healing second intention

capillaries of superficial plexus - blushing/sunburn

10

basement membrane

defines invasion of cancer
-proteins in blistering
-and other inflammatory conditions

11

superficial vascular plexus

in papillary dermis

12

rete pegs

interlock with dermal papillae

13

pacinian corpuscle

pressure receptor

encapsulated nerve endings

found in deep dermis or hypodermis

14

meissner corpuscles

touch receptor
-confined to dermal papillae
-hands and feet more numerous

15

skin nerve supply

free nerve endings - detect pain and temperature

sympathetic innervation - blood flow and hair movement

16

subQ tissue

hypodermis

adipocytes - lobules
fibroconnective tissue - septae

also - lots of blood vessels - deep plexus

connects reticular dermis with fascia of underlying tissue**

17

lobular paniculitis

pancreatitis

fat in subQ

18

septal paniculitis

erythema nododum

fibrous in subQ

19

function of hypodermis

1 - body temp regulation - vascular and adipose

2 - fat storage

3 - aging

20

skin wrinkling

loss of subQ adipose tissue in hypodermis

21

intrinsic aging

wrinkles

basal layer proliferation and risk of neoplasm

decrease in melanocytes - whitening

decreased langerhans cells

thinning

also decreased hair shaft diameter, decreased # of hair follicles, and redistribution of hair

22

actinic degeneration of reticular dermis collagen

solar elastosis

telangiectasias - dilated vessels close to surface also occurs

23

initial red with sunburn

vasodilation

24

sunburn changes

increased blood flow to dermis

superficial vessels - endothelial swelling

perivenular edema

perivascular inflammatory infiltrate

25

keratinocytes

squamous epithelial cells

26

elevated fluid filled lesion more than 5mm

bulla

27

linear traumatic epidermial disruption

excoriation
-deep scratch

28

thick rogh skin with prominent skin markings

lichenification
-repeated rubbing

29

flat circumscribed area 5mm or more that is colored

patch

30

flat circumscribed area less than 5mm that is colored

macule

31

separation of nail bed

onchyolysis

32

elevated dome shaped lesion <5mm

papule

33

elevated dome shaped lesion >5mm

nodule

34

elevated flat top lesion >5mm

plaque

35

discrete, pus-filled raised lesion

pustule

36

dry, horny, platelike excrescence
-result of imperfect cornification

scale

37

fluid filled raised lesion

bilster

38

fluid filled lesion >5mm

bulla

39

flui filled lesion >5mm

vesicle

40

itchy, transient, elevated lesion with variable blanching and erythema formed as result of dermal edema

wheal

41

loss of intercellular cohesion between keratinocytes

acantholysis

42

diffuse epidermal hyperplasia

acanthosis

43

abnormal, premature keratinization within cells below stratum granulosum

dyskeratosis

44

loss of epidermis

erosion

45

epidermal inflammatory cells

exocytosis

46

intracellular keratinocyte edema

hydropic swelling - ballooning

often with viral infections

47

Stratum granulosum hyperplasia, usually due to rubbing

hypergranulosis

48

Stratum corneum thickening, often with aberrant keratinization

hyperkeratosis

49

linear pattern of melanocyte proliferation within epidermal basal cell layer

lentiginous

50

surface elevation caused by hyperplasia and enlargement of contiguous dermal papilla

papillomatosis

51

keratinization with retained nuclei in stratum corneum

parakeratosis

normal in mucous membranes

52

intercellular edema of epidermis

spongiosis

53

discontinuity of skin showing complete loss of epidermis revealing dermis and subQ

ulceration

54

formation of vacuoles with or adjacent to cells

vacuolization