NSAIDs

Question 1

acetylsalicycliac acid

Answer 1

ASA

-aspirin

Question 2

propionic acid

Answer 2

iboprofen

naproxen

Question 3

indoleacetic acid

Answer 3

indomethacin

etodolac

Question 4

hereroaryl acetic acid

Answer 4

ketoralac

Question 5

COX 2 selective NSAID

Answer 5

celecoxib

Question 6

non-narcotic analgesic

Answer 6

acetaminophen

Question 7

weak anti-inflammatory

Answer 7

acetaminophen

Question 8

anti-inflammatory, analgesic, anti-pyretic

Answer 8

NSAIDs

Question 9

analgesis, antipyretic

Answer 9

acetaminophen

Question 10

NSAIDs MOA

Answer 10

inhibit COX - no PG synthesis

Question 11

precursor to PG

Answer 11

arachidonic acid

free AA enters 1 of 2 pathways

• COX - PG synthesis
• lipoxygenase - leukotriene synthesis

Question 12

COX1

Answer 12

most tissues present

housekeeping

Question 13

COX2

Answer 13

undetectable in most tissue

increased during inflammation

Question 14

irreversible inhibition of COX in platelets

Answer 14

aspirin

-used as anti-coag

Question 15

analgesic effect

Answer 15

PGE2 sensitizes pain nerve endings

Question 16

pyresis

Answer 16

cytokines, leukocytes, PGs in brain areas

Question 17

vasodilation

Answer 17

PGE2 and PGI2

blocked by NSAIDs

Question 18

apoptosis

Answer 18

PG inhibit apoptosis

NSAID - more apoptosis

used of NSAIDs and reduced risk of cancer

Question 19

dose of aspirin for anticoag

Answer 19

low dose needed - 85-160mg/day

Question 20

high dose aspirin

Answer 20

inhibit PGI2 - which is vasodilator and inhibitor of platelet

counterproductive for anticoag effect of aspirin

Question 21

renal function and NSAIDs

Answer 21

decreased renal blood flow
decrease rate of glomerular filtration

can result - renal failure

Question 22

reyes syndrome

Answer 22

CI for salicylates in children

with chicken pox of flu

Question 23

chicken pox or flu

Answer 23

no aspirin or other salicylates in children

use ibuprofen or naproxen instead

Question 24

NSAIDs other than aspirin

Answer 24

less side effect - particularly GI effects

Question 25

dysmennorhea

Answer 25

PG - cause cramping NSAID tx

Question 26

closure of patent ductus arteriousus

Answer 26

indomethacin

Question 27

preeclampsia and HTN in pregnancy

Answer 27

low dose aspirin

Question 28

colorectal cancer

Answer 28

reduced risk with chronic aspirin use

Question 29

burn off warts

Answer 29

topical salicyclic acid

Question 30

NSAID pharmacokinetic

Answer 30

liver metabolism kidney excretion 50-99% protein bound

Question 31

aspirin admin

Answer 31

should be take with food | -toxic to stomach lining

Question 32

analog of PGE1

Answer 32

misoprostol | -for chronic NSAID users

Question 33

CNS action of aspirin

Answer 33

due to salicylic acid aspirin does not cross BBB

Question 34

low dose aspirin

Answer 34

retain uric acid

Question 35

high dose aspirin

Answer 35

excrete uric acid

Question 36

gout patient

Answer 36

should not use aspirin for analgesia - causes retaining of uric acid

Question 37

anti-platelet dose of aspirin

Answer 37

160mg/day

Question 38

analgesia/antipyretic aspirin

Answer 38

2600mg/day

Question 39

anti-inflammatory aspirin

Answer 39

4000mg/day

Question 40

toxic dose of salicylates

Answer 40

respiratory depression

Question 41

ringing in ears

Answer 41

sign of salicylism - mild salicylate intoxication also - nausea, vomiting, hyperventilation, HA, mental confusion, dizzymnes

Question 42

third trimester of pregnancy

Answer 42

avoid aspirin and other NSAIDs reduced birth weights

Question 43

naproxen

Answer 43

best tolerated longer half life - less dosing through day

Question 44

tx rheumatoid arthritis, OA, ankylosing spondylitis, acute gout

Answer 44

indomethacin

Question 45

suppress contraction in preterm labor

Answer 45

indomethacin

Question 46

postop analgesia lasting 6-8 hours

Answer 46

etodolac relatively COX2 selective

Question 47

NSAID IM or IV

Answer 47

ketorolac limit to 5 days - because of GI toxicity

Question 48

selective COX2 inhibitor

Answer 48

celecoxib

Question 49

COX2

Answer 49

expressed constitituvely in brain and kidney target for anti-inflammation

Question 50

COX1

Answer 50

in platelets

Question 51

weak anti-inflammatory

Answer 51

acetaminophen only weak COX inhibitor

Question 52

acute overdose of acetaminophen

Answer 52

hepatotoxicity

Question 53

tx of acetaminophen toxicity

Answer 53

N-acetylcysteine - restore liver glutathione levels

Question 54

anti-leukotriene drugs

Answer 54

zafarlukast | montelukast