Joint and Soft Tissue Pathology II

Question 1

joint mice

Answer 1

calcium balls in joint space

Question 2

ganglion cyst

Answer 2

near joint capsule or tendon sheath

• common - around wrist
• cystic or myxoid degeneration of CT
• lacks cell lining

no communication with joint space

Question 3

synovial cyst

Answer 3

herniation through joint capsule

Question 4

synovial cyst forming in popliteal space in RA

Answer 4

baker cyst

herniation of cyst in knee

Question 5

aspiration of ganglion cyst

Answer 5

thick/mucus

Question 6

benign neoplasms in synovial lining ofjoints, tendon sheaths, and bursae

Answer 6

tenosynovial giant cell tumor

diffuse type and localized type

Question 7

pigmented villonodular synovitis

Answer 7

diffuse tenosynovial giant cell tumor

large joints

Question 8

giant cell tumor of tendon sheath

Answer 8

localized tenosynovial giant cell tumor

discrete nodule attached to tendon sheath in hand

Question 9

tiger striped

Answer 9

tenosynovial giant cell tumor

Question 10

below fascia

Answer 10

malignant

Question 11

above fascia

Answer 11

benign

Question 12

knee pain, locking, recurrent swelling, with palpable mass

Answer 12

diffuse tenosynovial giant cell tumor

Question 13

soft tissue tumors

Answer 13

benign outnumber malignant

Question 14

big lesion in thigh

Answer 14

think soft tissue neoplasm

Question 15

t(11;22)

Answer 15

ewing sarcoma

Question 16

spindle cells and groups of epithelioid cells - biphasic

Answer 16

synovial sarcoma

Question 17

herring bone

Answer 17

fibrosarcoma

Question 18

palisading - nuclei in columns

Answer 18

schwann cell

Question 19

storiform - short fascicles of spindle cells from central point - spokes on a wheel

Answer 19

fibrohistiocytic

Question 20

fascicles of eisinophils intersecting at right aingles

Answer 20

smooth muscle

Question 21

benign tumor of fat

Answer 21

lipoma

Question 22

most common soft tissue tumor of adulthood

Answer 22

lipoma

Question 23

well encapsulated mass of adipocytes

Answer 23

lipoma

Question 24

painful tumors

Answer 24

GLENDA

angiolipoma = A

Question 25

soft, mobile, painless

Answer 25

lipoma except angiolipoma - is painful

Question 26

most common sarcoma of adulthood

Answer 26

liposarcoma age 50-60yo deep soft tissues

Question 27

liposarcoma with abundant ground substance and rich capillary network with scattered immature adipocytes and stellate cells

Answer 27

myxoid

Question 28

liposarcoma with mature adipocytes and scattered spindle cells

Answer 28

well-differentiated liposarcoma

Question 29

23yo F, soccer, hit in shin, develop swelling large mass week later

Answer 29

nodular fasciitis

Question 30

history of trauma

Answer 30

nodular fasciitis

Question 31

nodular fasciitis

Answer 31

fibroblastic and myofibroblastic proliferation typically in younger adults in upper extremity with history of trauma**

Question 32

superficial fibromatosis

Answer 32

infiltrative fibroblastic proliferation that can cause local deformity more in males nodular or poorly defined broad fascicles of fibroblasts surrounded by abundant dense collagen

Question 33

irregular thickening of palmar fascia

Answer 33

dupuytrens contracture subtype of superficial fibromatosis

Question 34

peyronie disease

Answer 34

penile superficial fibromatosis mass on dorsolateral aspect of penis -eventual curvature of shaft

Question 35

subtypes of superficial fibromatosis

Answer 35

palmar plantar penile

Question 36

deep fibromatosis

Answer 36

desmoid tumor large, infiltrative mass that frequently recur no mets teens to 30yo in abdomen

Question 37

desmoid tumor

Answer 37

extra-abdominal- shoulder, chest wall, back, thigh abdominal - anterior abdominal wall in women around pregnancy intra-abdominal - mesentery or pelvic wall - individuals with familial adenomatous polyposis

Question 38

C section scar

Answer 38

turn to extra-abdominal desmoid tumor

Question 39

belly dancer

Answer 39

desmoid tumor - abdominal

Question 40

skeletal muscle tumors

Answer 40

almost all malignant**

Question 41

patient with TB

Answer 41

benign rhabdomyoma

Question 42

subtypes of rhabdomyosarcoma

Answer 42

alveolar - 20% embryonal - 60% pleomorphic - 20%

Question 43

alveolar rhabdomyosarcoma

Answer 43

kids

Question 44

embryonal rhabdomyosarcoma

Answer 44

majority | kids

Question 45

pleomorphic rhabdomyosarcoma

Answer 45

adults

Question 46

grape like

Answer 46

sarcoma botryoides | -embryonal rhabdomyosarcoma

Question 47

sarcoma botryoides

Answer 47

grape like | rhabdomyosarcoma

Question 48

cambium layer

Answer 48

submucosal zone of hypercellularity | -in embryonal rhabdomyosarcoma

Question 49

tx of rhabdomyosarcoma

Answer 49

aggressive | -surgery and chemo

Question 50

best prognosis rhabdomyosarcoma

Answer 50

embryonal rhabdomyosarcoma - botryoid variant

Question 51

pleomorphic rhabdomyosarcoma prognosis

Answer 51

fatal

Question 52

uterus

Answer 52

leiomyoma

Question 53

benign smooth m tumor

Answer 53

leiomyoma often in uterus

Question 54

arise of leiomyoma

Answer 54

often in erector pilar muscles -pilar leiomyoma may be multiple and painful

Question 55

volcano lesion

Answer 55

GIST tumor - c-kit positive in stomach smooth m

Question 56

eosinophilic spindle cells in interweaving fascicles

Answer 56

leiomyosarcoma

Question 57

mets of leiomyosarcoma

Answer 57

to lungs

Question 58

muscle specific actin immunostain

Answer 58

leiomyosarcoma

Question 59

synovial sarcoma

Answer 59

often around knee -age 20-40yo morph - monophasic or biphasic

Question 60

positive for epithelial markers - keratins

Answer 60

synovial sarcomas

Question 61

biphasic spindle cell and gland like histo appearnace

Answer 61

synovial sarcoma

Question 62

tx of synovial sarcoma

Answer 62

aggressive -chemo and therapy mets to lungs

Question 63

malignant fibrous histiocytoma

Answer 63

now called - undifferentiated pleomorphic sarcoma

Question 64

fascicles of plump spindle cells in swirling storiform pattern

Answer 64

pleomorphic fibrosarcoma

Question 65

herring bone pattern of malignant spindle cells

Answer 65

fibrosarcoma

Question 66

UPS

Answer 66

undifferentiated pleomorphic sarcoma high grade pleomorphic cells cannot be classified into another category largest category of adult sarcomas aka - malignant fibrous histiocytoma - term no longer used