Bone (Histology and Physiology)

Question 1

Osseous Tissue

Answer 1

Makes up bone
- Supporting Connective Tissue

Question 2

Matrix of Bone Consists of?

Answer 2

• Calcium Phosphate (2/3 of Bone Mass)
• Hydroxyapatite Crystal
• Collagen Fibers (1/3 of Bone Mass)
• Bone Cells (2% of Bone Mass)

Question 3

Hydroxyapatite Crystal function?
How is it made?

Answer 3

Resists compression
Converted from Calcium Phosphate

Question 4

Collagen Fibers function?

Answer 4

Tensile Strength

Question 5

What makes Bone Tissue Strong

Answer 5

Hydroxyapatite Crystals
Collagen

Question 6

Osteocytes

Answer 6

Mature bone cells

Triggers bone remodeling

Question 7

Osteocytes (Where?)

Answer 7

Lies in depressions called Lacunae
Matrix Layer = Lamella

Question 8

Osteocytes (Derived from?)

Answer 8

From osteoblasts that have been buried by their own matrix

Question 9

Channels from Osteocytes to Capillaries

Answer 9

Canaliculi

Question 10

Osteoblasts

Answer 10

Immature bone cells

Makes new bones by producing osteoid

Question 11

Osteoblasts (Where?)

Answer 11

Lies on the surface of bones

Question 12

Osteoprogenitor Cells

Answer 12

Bone Stem Cells

Form new osteoblasts
Involved in making new bones after a break

Question 13

Osteoclasts

Answer 13

Giant Multinucleated Cells (From Macrophages)

Secretes acid which dissolve bone and releases stored calcium

Question 14

Osteogenesis

Answer 14

Osteoblasts

Question 15

Osteolysis

Answer 15

Osteoclasts

Question 16

ARRF Process

Answer 16

Activation
Resorption
Reversal
Formation

Question 17

Activation

Answer 17

Osteoclasts dig hole and acidify bone

Question 18

Resorption

Answer 18

Ca2+ is released and leaves the bone

Question 19

Reversal

Answer 19

Swap from losing bone to gaining bone

Question 20

Formation

Answer 20

Osteoblasts fill back the lost space with new bone

Question 21

What promotes Mineralization of Bone

Answer 21

pH (Alkaline)
Nucleation ()
Crystal Propagation (Enough Ca, PO4)