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Flashcards in Bordetella Pertussis Deck (12):
1

Characteristics of B. Pertussis x2

- small
- gram -ve cocci

2

Highly significant in which age groups? What complications could follow?

Highly significant in children

3

Clinical features x3

- insidious onset
- catarrhal stage with common cold symptoms
- paroxysmal coughing
- residual cough

4

Symptoms of whooping cough

- shortness of breath during coughing
- nocturnal coughing
- post-tussive vomitting
- tingling sensation in back of throat

5

Mode of action of b. Pertusis

The organism infects the ciliated epithelial layer of the respiratory tract without invading deeper, resulting in acute tracheobronchitis

6

Name 2 things that aid the invasion of the epithelial layer

Pertussis toxin
Filamentous hemagglutinin

7

What is the outer membrane protein that promotes its attachment to tracheal epithelial cells?

Pertactin

8

What is the function of pertactin?

It promotes the attachment of bordetella pertussis to tracheal epithelial cells

9

Name 4 toxins involved with b.pertussis

- pertussis toxin
- adenylate cyclase / hemolysin
- tracheal cytotoxin
- lipopolysaccharide (endotoxin)

10

Diagnosis of B. Pertussis

Hold BG culture plate in front of mouth when coughing
Perinasal swab of posterior pharyngeal walls

11

Treatment of B. Pertussis

Erythromycin for 14 days
Skilled nursing, removal of mucous and vomit

12

What does bordetella pertussis cause?

Whooping cough