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Flashcards in Neisseria Deck (16):
1

Characteristics of Neisseria

- gram negative
- diplococci
- aerobes
- oxidase positive
- catalase positive
- produces cytochrome oxidase
- oval organisms in pairs/small clumps
- non-motile
- do not form endospores

2

Name two species of neisseria

n. Gonorrhoea
N. Meningitidis

3

What does N. Gonorrhoea cause? (X4)

- gonorrhoea (STD)
- cervicitis
- pelvic inflammatory disease
- pharyngitis

4

Name 4 virulence factors that promote the actions of N. Gonorrhoea

- simple capsule and pili
- Opa proteins (OMP II) facilitate adhesion
- Pili enables organism to resist phagocytosis
- IgA protease produced

5

Identification of N. Gonorrhoea

Swabs of infected material
Gram stain, intracellular gram negative diplococci
Cooked blood agar
Oxidase positive
Glucose positive
Maltose and sucrose negative

6

Treatment of N. Gonorrhoea

Penicillin
Cephalosporins and second antibiotic

7

What does N. Meningitidis cause? Name 2 other bacteria that causes the same disease

Acute suppurative meningitis
Also caused by S. Pneumonia and H. Influenza

8

What is meningitis?

The infection and inflammation of membranes covering the brain and spinal cord (meninges + CSF)

9

Reservoir of N. Meningitidis

In the nasopharynx of 5-10% of the population

10

Transmission of N. Meningitidis

Spread by infected carrier via respiratory secretions

11

To which age group is N. Meningitidis the greatest threat?

Children under 5 years old

12

Initial symptoms of disease caused by N. Meningitidis (x4)

- abrupt onset
- malaise
- high fever (40deg)
- possible rash (bloodstream)

13

Identification of N. Meningitidis (x5)

- non-motile
- gram negative diplococci
- oxidase-positive
- cultured on CBA/chocolate agar
- ferments glucose and maltose

14

Diagnosis of N. Meningitidis

Sampling of CSF
Serogroup specific anti-capsular antibody reactions

15

Control of N. Meningitidis

- Meningococcal C conjugate (MenC)
- Meningococcal B

16

Name 3 locations where neisseria can be found

- oropharynx
- nasopharynx
- anogenital mucosal membranes