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Flashcards in H. Influenza Deck (13):
1

Specific growth requirements of H. Influenza x3

- "choc" or cooked blood agar
- aerobic
- nutritional factors 'X' (haematin) and 'V' (nicotinamide adenine dinucleotide)

2

Pathogenesis of H. Influenza

bacteria attaches to epithelial cells and organism penetrates sub mucosa of nasopharynx, causing local inflammation and swelling, as it spreads from the initial site to infect bones, joints and CNS

3

Transmission of H. Influenza

Infection from respiratory droplet/direct contact w patient

4

What is the X nutritional factor?

Haematin

5

What is the V nutritional factor?

Nicotinamide adenine dinucleotide (NAD)

6

Which type of blood agar does H. Influenza grow better in? Why?

Cooked blood agar is better than normal blood agar bc the V factor is imprisoned in intact RBCs

7

Significance of capsule of H. Influenza

Protects the bacteria from phagocytosis, reducing its susceptibility to the antibacterial role of serum

8

What is the H. Influenza capsule made up of

Polyribosyl Ribotol phosphate

9

Name 3 adhesins of H. Influenza

- P2
- fimbriae/Pili
- non-pilus adhesins

10

Treatment of meningitis caused by H. Influenza

Antibiotics - cefotaxime and related cephalosporins e.g. Ceftriaxone

11

Treatment of bronchitis caused by H. Influenza

Antibiotics: amoxicillin/erythromycin

12

Treatment of pneumonia caused by H. Influenza

Antibiotics: flucloxacillin, Amoxycillin

13

Characteristics of H. Influenza x3

- small
- gram neg bacilli
- non-motile