Flashcards in H. Influenza Deck (13)
Specific growth requirements of H. Influenza x3
- "choc" or cooked blood agar
- nutritional factors 'X' (haematin) and 'V' (nicotinamide adenine dinucleotide)
Pathogenesis of H. Influenza
bacteria attaches to epithelial cells and organism penetrates sub mucosa of nasopharynx, causing local inflammation and swelling, as it spreads from the initial site to infect bones, joints and CNS
Transmission of H. Influenza
Infection from respiratory droplet/direct contact w patient
What is the X nutritional factor?
What is the V nutritional factor?
Nicotinamide adenine dinucleotide (NAD)
Which type of blood agar does H. Influenza grow better in? Why?
Cooked blood agar is better than normal blood agar bc the V factor is imprisoned in intact RBCs
Significance of capsule of H. Influenza
Protects the bacteria from phagocytosis, reducing its susceptibility to the antibacterial role of serum
What is the H. Influenza capsule made up of
Polyribosyl Ribotol phosphate
Name 3 adhesins of H. Influenza
- non-pilus adhesins
Treatment of meningitis caused by H. Influenza
Antibiotics - cefotaxime and related cephalosporins e.g. Ceftriaxone
Treatment of bronchitis caused by H. Influenza
Treatment of pneumonia caused by H. Influenza
Antibiotics: flucloxacillin, Amoxycillin