Brain Tumor Markers

Question 1

GFAP +, astrocyte origin:

Answer 1

glioblastoma multiforme

Question 2

GFAP +, oligodendrocyte origin:

Answer 2

oligodendroglioma

Question 3

arachnoid villi origin:

Answer 3

meningioma

Question 4

blood vessel origin:

Answer 4

hemangioblastoma

Question 5

S-100 +, schwann cell origin:

Answer 5

schwannoma

Question 6

GFAP stains tumors from what origin?

Answer 6

glial origin–astrocytes, oligodendrocytes, ependymal cells

Question 7

Synaptophysin stains tumors from what origins?

Answer 7

neuronal origin–neuroectodermal or neuroendocrine

Question 8

pseudopallisading pleomorphic tumor cells tha border central area of necrosis, hemorrhage and/or microvascular proliferation:

Answer 8

glioblastoma multiforme

Question 9

fried egg cells, often calcified:

Answer 9

oligodendroglioma

Question 10

spindle cells concentrically arranged in a whorled pattern (psamomma bodies–dystrophic calcification)

Answer 10

meningioma

Question 11

closely arranged thin walled capillaries with minimal intervening parenchyma

Answer 11

hemangioblastoma

Question 12

brain tumor associated with VHL syndrome

Answer 12

hemangioblastoma

Question 13

dense, hypercellular areas contianing spindle cells with hypocellular myxoid areas

Answer 13

schwannoma

Question 14

found in cerebral hemishperes, can cross midline:

Answer 14

glioblastoma multiforme

Question 15

chicken wire capillary pattern, most often in frontal lobes:

Answer 15

oligodendroglioma

Question 16

occurs near surfaces of brain, near the parasagittal region; may have a dural attachment

Answer 16

meningioma

Question 17

can produce EPO:

Answer 17

hemangioblastoma

Question 18

classically at cerebellopontine angle:

Answer 18

schwannoma

Question 19

if seen BL at cerebellarpontine angle:

Answer 19

BL schwannoma associated with NF2

Question 20

GFAP positive, rosenthal fibers:

Answer 20

pilocytic astrocytoma

Question 21

most common benign primary childhood brain tumor; arises in the posterior fossa

Answer 21

pilocytic astrocytoma

Question 22

most common malignant brain tumor in childhood:

Answer 22

medulloblastoma

Question 23

usually involves the cerebellum and can compress the 4th ventricle

Answer 23

medulloblastoma

Question 24

primitive neuroectodermal tumor with Homer Wright rosettes on histo:

Answer 24

medulloblastoma

Question 25

ependymal cell origin:

Answer 25

ependymoma

Question 26

usually found from originating from the roof of the 4th ventricle:

Answer 26

ependymoma

Question 27

perivascular pseudorosettes with rod shaped blepharoplasts found near nucleus:

Answer 27

ependymoma

Question 28

derived from Rathke’s pouch:

Answer 28

craniopharyngioma

Question 29

calcification with cholesterol crystals found in motor-oil like fluid:

Answer 29

craniopharyngioma

Question 30

tumor of the pineal gland:

Answer 30

pinealoma

Question 31

brain tumor that secretes b-HCG

Answer 31

pinealoma

Question 32

brain tumor that can cause Parinaud syndrome:

Answer 32

pinealoma

Question 33

Damage to the dorsal midbrain:

vertical gaze palsy
pupillary light-near dissociation
lid retraction
convergence-retraction nystagmus

Answer 33

Parinaud syndrome

Question 34

codeletion of 1p and 19q

Answer 34

oligodendroglioma