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Flashcards in BREAST PATHOLOGY Deck (17):
1

Unilateral breast mass

bloodly nipple discharge

                         Fixation to underlying chest wall

Gross: firm to hard , irregular border

Microscopy: extensive desmoplasia, tubules, solid clusters or single infiltrating cells with necrosis and atypical mitoses

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Invasive Ductal Carcinoma

2

Mechanism responsible for this appearance

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Dermal lymphatic invasion by malignant tumor cells

3

6th decade

unilateral breast mass

Gross: Bulbous protrusions

Microscopy:  increased stromal cellularity and overgrowth --> leaflike architecture

 

 

 

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Phyllodes Tumor

4

List 4 causes for pathologic gynecomastia

Cirrhosis MCC

Klinefelter syndrome

spironolactone, ketoconazole

Leuprolide

5

List 4 causes for galactorrhea

Physiologic

Prolactinoma

Primary hypothyroidism

Drugs-eg: H2-receptor blockers

6

vitamin A deficiency associated with smoking

keratinizing squamous metaplasia of the nipple ducts

painful erythematous subareolar mass

Periductal Mastitis

7

30 year old female

discrete movable, painless breast mass

Gross: §well-circumscribed, rubbery, grayish white nodules that bulge, slitlike spaces

Microscopy: See attached image

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Fibroadenoma

8

1. Diagnosis?

•malignant clonal population of cells limited to ducts and lobules by the basement membrane.

solid sheets of pleomorphic cells with “high-grade” hyperchromatic nuclei and areas of central necrosis

2. Mammography feature of this condition

 

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1. DCIS- comedo type

2.clusters or linear and branching microcalcifications 

9

Diagnosis?

Bloody nipple discharge

See attached image

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Intraductal papilloma

10

What is the mcc of this lesion?

Localized, firm breast mass

M/E: irregular steatocytes with no peripheral nuclei 

pink amorphous necrotic material and inflammatory cells

foreign body giant cells

lipid laden macrophages

 

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breast trauma or prior surgery.

11

List the morphologic changes assoc with fibrocystic change

Cystic change

apocrine metaplasia

Fibrosis

Adenosis

12

1. Diagnosis?

Breast mass

dyscohesive infiltrating tumor cells, in single file or in loose clusters or sheets

minimal desmoplasia

2. An important feature to note in terms of laterality of this tumor?

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1. Invasive Lobular Carcinoma

2. 20% are bilateral

13

unilateral erythematous eruption with a scale crust

bloody nipple discharge

pruritus+/-

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Paget disease

14

  • 50-60 years
  • poorly defined palpable periareolar mass
  • •Greenish brown nipple discharge
  • M/E: Chronic inflammation and fibrosis surround an ectatic duct filled with inspissated debris

 

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Mammary Duct Ectasia

15

Causes for granulomatous mastitis

Silicone implants

Sarcoidosis

Wegner's granulomatosis

Mycobacterial/ fungal infections

16

Breastfeeding new mother

Infant with cleft palate

Mother presents with erythema and pain in the breast, has fever

Acute mastitis

17

Most important prognostic factor for breast carcinomas in the absence of distant metastasis

Axillary lymph node status