LUNG PATHOLOGY -2 Flashcards Preview

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Flashcards in LUNG PATHOLOGY -2 Deck (23)
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1
Q

List 3 IHC markers that would confirm a diagnosis of small cell carcinoma

Deborah Dalmeida MD

A

Chromogranin

Neuron specific enolase

Synaptophysin

Deborah Dalmeida MD

2
Q

Which of the following points represents a restrictive lung disease?

Deborah Dalmeida MD

A

D

Deborah Dalmeida MD

3
Q

Features of carcinoid syndrome

Deborah Dalmeida MD

A

Bronchospasm

Flushing

Diarrhea

Right sided heart murmur

Deborah Dalmeida MD

4
Q

Where do the tumor cells grow in bronchioloalveolar carcinoma?

Deborah Dalmeida MD

A

along the walls of pre existing alveoli – lepidic pattern

Deborah Dalmeida MD

5
Q

What’s your diagnosis?

List the 3 most common conditions responsible for this appearance.

Deborah Dalmeida MD

A

Cannon ball metastases

Commonest primary sites: Breast > colon>renal

Deborah Dalmeida MD

6
Q

What’s the cell of origin of these tumor cells?

Deborah Dalmeida MD

A

Neuroendocrine Kulchitsky cells

Deborah Dalmeida MD

7
Q

Highly malignant neoplasm a/w heavy exposure to asbestos

Deborah Dalmeida MD

A

Mesothelioma

Deborah Dalmeida MD

8
Q

What’s your diagnosis?

Central mass

Light microscopy: organoid arrangement of tumor cells

Electron microscopy - dense-core granules

Flushing

Diarrhea

Deborah Dalmeida MD

A

Carcinoid Tumor

Deborah Dalmeida MD

9
Q

Tall, thin males around the age of 20

Smoking

Deborah Dalmeida MD

A

Primary spontaneous Pneumothorax

Deborah Dalmeida MD

10
Q

List the possible structures that may be possibly involved in Pancoast tumor.

Deborah Dalmeida MD

A
  • Recurrent laryngeal nerve - hoarseness
  • Stellate ganglion à Horner syndrome (ipsilateral ptosis, miosis, anhidrosis)
  • Superior vena cava - SVC syndrome
  • Brachiocephalic vein
  • Brachial plexus

Deborah Dalmeida MD

11
Q

central tumor

organoid, trabecular, palisading, ribbon, or rosette-like arrangements of cells separated by a delicate fibrovascular stroma

Electron microscopy shows dense core granules

Deborah Dalmeida MD

A

Carcinoid Tumor

Deborah Dalmeida MD

12
Q
  1. The lung carcinoma most commonly associated with ectopic hormone production as part of paraneoplastic syndrome
  2. List two ectopic hormone syndromes occuring as a part of paraneoplastic syndromes

Deborah Dalmeida MD

A
  1. Small cell Carcinoma (Oat cell carcinoma)
  2. Ectopic ACTH and SIADH

Deborah Dalmeida MD

13
Q

Central mass

small round or polygonal cells in clusters with salt and pepper pattern of nuclear chromatin

Electron microscopy- dense core neurosecretory granules

Deborah Dalmeida MD

A

Small cell carcinoma (Oat cell carcinoma)

Deborah Dalmeida MD

14
Q

peripheral, solitary, well circumscribed,

solitary coin lesion on the CXR

Deborah Dalmeida MD

A

Pulmonary Hamartoma

Deborah Dalmeida MD

15
Q

Why would you get Horner Syndrome secondary to a lung tumor?

Features of Horner Syndrome?

Deborah Dalmeida MD

A

Involvement of sympathetic ganglia

Ptosis, miosis, anhydrosis, enophthalmos, loss of cilisospinal reflex

Deborah Dalmeida MD

16
Q

Which of the following points represents an obstructive disease?

Deborah Dalmeida MD

A

A

Deborah Dalmeida MD

17
Q

central mass

association with smoking

gray white

tendency to cavitate

Deborah Dalmeida MD

A

Squamous cell carcinoma

Deborah Dalmeida MD

18
Q
  1. Hypercalcemia is seen occuring as a paraneoplastic syndrome with which subtype of lung carcinoma
  2. What is the substance being elaborated causing hypercalcemia?

Deborah Dalmeida MD

A
  1. Squamous cell carcinoma
  2. Parathyroid hormone-related peptide

Deborah Dalmeida MD

19
Q

peripherally located mass

non smokers, women

positive for thyroid transcription factor-1 (TTF-1)

80% contain mucin.

Deborah Dalmeida MD

A

adenocarcinoma

Deborah Dalmeida MD

20
Q

List 3 causes for the condition shown in the attached image

Deborah Dalmeida MD

A
  • malignancy invading/compressing the SVC (eg, mediastinal mass, Pancoast tumor)
  • thrombosis from indwelling catheters

Deborah Dalmeida MD

21
Q

What is this ?

Periosteal new bone formation, Clubbing, Arthritis

Deborah Dalmeida MD

A

Hypertrophic osteoarthropathy

Deborah Dalmeida MD

22
Q

Xaxis represents number of breaths per minute

Y axis represents the work of breathing

Does this graph represent a restrictive or an obstructive effect?

Deborah Dalmeida MD

A

Restrictive defect

Deborah Dalmeida MD

23
Q

Xaxis represents number of breaths per minute

Y axis represents the work of breathing

Does this graph represent a restrictive or an obstructive effect?

Deborah Dalmeida MD

A

Obstructive

Deborah Dalmeida MD