cAMP and metabolism Flashcards
what are the 4 hormones associated with fasting and increasing blood glucose levels
glycogon
adrenaline
cortisol
growth hormone
what is the hormone associated with well fed state and decreasing blood glucose levels
insulin
how do glycogen and catecholamines exert their effect
via increasing cellular concentrations of cAMP
what is catecholamine
a neurotransmitter
what is cAMP
cytosolic adenosine monophosphate
messenger used for intracellular signaling
what places in the body do glycogen and catecholamines effect
the liver and the adipose tissue
what place in the body does catecholamines Soley affect
the muscles
what happens when cAMP is increased
increase of lipolysis
increase in gluconeogenesis
increase glycogenolysis
increase in Fatty acid oxidation
activation of receptors leads to what
a change in shape/stimulation of a protein called Gs
what does Gs do once its activated
activates adenylate cyclase
what does adenylate cyclase do
converts ATP to cAMP
what can cAMP do
freely diffuse out of the membrane through to the cytosol looking for targets to bind to
what does cAMP bind to
protein kinases (most important is protein kinase A)
what does protein Kinase A do
adds phosphate groups to enzymes to either increase or decrease their activity
what enzymes are activated by phosphorylation from PKA
glycogen phosphorylase
fructose-1,6-phosphorylase
