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Cancer Chemotherapy Flashcards

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1
Q

Toxic effects of vincristine ?

A

Peripheral neuropathy

( check chemo man )

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2
Q

Toxic effect of bleomycin?

A

Pulmonary fibrosis

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3
Q

Toxic effect of Methotrexate?

A

Myelosuppression

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4
Q

Toxic effect of Doxorubicin ?

A

Cardiotoxicity

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5
Q

Chemotherapeutic drug that may cause hemorrhagic cystitis ?

A

Cyclophosphamide

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6
Q

Rescue therapy for doxorubicin toxicity?

A

Dexrazoxane

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7
Q

Rescue therapy for Cyclophosphamide toxicity?

A

MESNA

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8
Q

Rescue therapy for Methotrexate toxicity?

A

Leucoverin

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9
Q

Rescue therapy for cisplatin toxicity?

A

Amifostine

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10
Q

Drugs causing pulmonary fibrosis? (6)

A

“BagA Na MatiGas”
1. Busulfan
2. Bleomycin
3. Bromocriptine
4. Amiodarone
5. Nitrofurantone
6. Methotrexate

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11
Q

Moa of Etoposide?

A

“eTWOposide”
Inhibits DNA topoisomerase-II (DNA Gyrase)

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12
Q

Drug for breast , colorectal, head and neck cancer that acts by causing a thymine-less death of cells?

A

5-FU

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13
Q

All-trans retinoic acid is used for what malignancy?

A

Acute promyelocytic leukemia

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14
Q

Drug that may be given to advanced prostate cancer?

A

Leuprolide

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15
Q

Must be given to prostate cancer patient in combination with Leuprolide who is at risk for a flare with exacerbation of pain and increase in obstructive symptoms?

A

Bicalutamide

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16
Q

Possible drug being given to a patient with chronic myelogenous leukemia who presented with pulmonary fibrosis?

A

Busulfan

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17
Q

Used in the treatment of colorectal cancer, non-small cell lung, and renal cancer which inhibits the binding of VEGF to its receptor, thereby preventing tumor vascularization.

A

Bevacizumab

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18
Q

Inhibits the binding of EGF tothe HER-2 / neu growth recpetor.

A

Transtuzumab

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19
Q

Inhibits bcr-abl tyrosine kinase and other receptor tyrosine kinases?

A

Imatinib

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20
Q

Reversibly inhibits the chymotrypsin-like activity of the 26S proteasome and is used in the treatment of multiple myeloma?

A

Bortezomib

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21
Q

Nephrotoxic effect of Cisplatin mitigate renal damage by combining with what agent?

A

Mannitol

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22
Q

Agent combined with anthracyclines (doxorubicin) to protect its cardiotoxicity, which inhibits free radical formation.

A

Dexrazoxane

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23
Q

Agent which traps acrolein produced from cyclophosphamide reducing its occurrence of hemorrhagic cystitis?

A

MESNA - Mercaptoethanesulfonate

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24
Q

Anticancer drugs used in acute leukemia which acts by blocking the formation of mitotic spindle by preventing the assembly of tubulin dimers into microtubules?

A

Vinca alkaloids

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25
Induce DNA damage by inhibiting topoisomerase I.
Camptothecins : Topotecan, Irinotecan
26
Agents moa Intercalate DNA base pairs, inhibit topoisomerase II and generate free radicals.
Anthracyclines: Doxorubicin, Daunorubicin, Idarubicin, Epirubicin and Mitoxantrone
27
Agent administer with methotrexate to mitigate its bone marrow suppression effect and mucositis?
Folinic Acid ( Leucovorin)
28
29
Synthetic peptides that are GnRH agonist? (5)
Leuprolide Goserelin Histrelin Nafrelin Triptorelin
30
GnRH antagonists (3)
Ganirelix Cetrorelix Degarelix
31
Growth hormone receptor antagonist used in acromegaly?
Pegvisomant
32
33
What phase does epipodophyllotoxins inhibit?
G-1 , S-phase
34
Other name for VP-16?
Etoposide
35
Other name for VM-26?
Teniposide
36
Vinca alkaloids disrupt what phase in the cell cycle?
M-Phase
37
Other name for Oncovin?
Vincristine
38
Taxanes disrupt what phase in the cell cycle?
M-phase
39
Bleomycin disrupt what phase in the cell cycle?
G-2, M phase
40
Ixabepilone disrupt what phase in the cell cycle?
Microtubule Inhibitor in the M-phase.
41
Examples of epipodophyllotoxins? (2)
Etoposide Teniposide
42
Anti-folates used for anti-neoplastic? (3)
Metothrexate Pemetrexed Pralatrexate
43
Fluoropyrimidines used for Anti-neoplastic ? (4)
5-FU Capecitabine Cytarabine Gemcitabine
44
Drug which inhibit the Receptor Tyrosine Kinase ( RTK ) : (2) VEGF- R2, R3 PDGFR-B raf-K
Sorafenib Pazopanib
45
Drug which inhibit the Receptor Tyrosine Kinase ( RTK ) : PDGFR-A, B VEGF- R1, R2, R3 C-kit
Sunitinib
46
DOC for ALL ?
Vincristine + Prednisone IT MTX, 6-MP, Cyclophosphamide, Vincristine, Daunorubicin, Aspargine
47
DOC for AML ?
Cytarabine + Idarubicin + G-CSF
48
DOC for CLL ?
Chlorambucil + Cyclophosphamide + Fludarabine + Rituximab
49
DOC for CML ?
Imatinib + Busulfan + IFN-a , H-urea
50
DOC for Breast Cancer ?
Tamoxifen / Anastrozole CMF ( Cyclophosphamide + MTX+ 5-FU) FAC ( 5-FU + Doxorubicin - Adriamycin + Cyclophosphamide) FEC ( 5-FU + Epirubicin + Cyclophosphamide) Transtuzumab + Anthacycline / Tamoxifen
51
DOC for Cervical Cancer ?
Cisplatin + Carboplatin
52
DOC for Colorectal Cancer ?
5-FU + Oxali + Leuco Fulfox + Cape 5-FU + Leucov + Irino + Folfiri + Bevacizumab + Cituximab / Panitu
53
DOC for Lung Cancer ?
Carboplatin + Etoposide / Paclitaxel + Bevaci Cisplatin + Irinotecan / Topo
54
DOC for Ovarian Cancer ?
Carboplatin + Paclitaxel + Topo
55
DOC for Pancreatic Cancer ?
Gemcitabine + Erlotinib
56
DOC for Prostate Cancer ?
Leuprorelin + Flutamide / Bicalu Docetaxel + Prednisone ( Hor.Ref)
57
DOC for Stomach Cancer ?
5-FU + Cisplatin + Irinotecan / Paclitaxel + Tras + Capecitabine
58
DOC for Hepatocellular Carcinoma ?
Unresectable : Sorafenib (TK)
59
DOC for Brain Cancer ?
PCV + Bevaci Procar + Carmus + Vincristine + Bevaci
60
DOC for Hodgkin’s SA ?
ABVD Adria + Bleomycin + Vinblastine + Dacarna Stanford V + Radiotherapy
61
DOC for Non-Hodgkins SA ?
CHOP Cyclophosphamide + Doxorubicin + Vincristine + Predni + Rituximab ( Anti-CD20)
62
DOC for Testicular Cancer ?
PEB Cisplatin + Etoposide + Bleomycin
63
DOC for Thyroid Cancer ?
RDC I-131 + Doxorubicin + Cisplatin
64
DOC for Head and Neck Cancer ?
FC/ CP 5-FU + Cisplatin or Cisplatin + Paclitaxel
65
DOC for Choriocarcinoma ?
M/ EC MTX+ Etoposide / Cisplatin
66
DOC for Osteogenic SA?
D/ ML Doxorubicin + MTX / Leucov
67
DOC for Melanoma?
DCT Dacarba , Cisplatin, Temozo + INF-a + IL-2
68
DOC for Multiple Myeloma ?
MPB Melpha + Prednisone + Lenalidomide + Dexa + Bortezomib VAD Vincristine + Doxo + Dexa + Thalidomide + Bortezomib
69
DOC for Insulinoma ?
Streptozocin + IFN-A
70
DOC for Hemorrhagic Cystitis?
Cyclophosphamide
71
DOC for Pulmonary Fibrosis ?
Busulfan Bleomycin
72
DOC for Renal and Acoustic Dysfunctions?
Platinum
73
DOC for Megaloblastic anemia ?
MTX Cytarabine 5-FU
74
Chemotherapy known for its Cardiotoxicity ( Congestive Cardiomyopathy) as its adverse reaction?
Adriamycin
75
Hepatotoxic anti-neoplastic agents ? (3)
6-MP 6-TG Asparginase
76
Antineoplastic known to have an Arterial thromboembolic adverse effect?
Bevacizumab
77
Antineoplastic known to produce SIADH as its adverse effect?
Vincristine, Vinorelbine, Vinblastine
78
Antineoplastic known to cause immunosupression as its adverse effect?
Corticosteroids
79
Antineoplastic known to cause Hypomagnesemia as its adverse effect?
Cetuximab / Panitumumab
80
Antineoplastic known to cause hand foot syndrome as its adverse effect?
Capecitabine / Pemetrexed

Pharmacology (20 decks)

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