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Flashcards in cancer drugs Deck (30):
1

FRONT

BACK

2

This class of cancer drug is cell-cycle non-specific and substitutes and alkyl group for a hydrogen atom which results in interference of DNA replication and RNA transcription:

alkylating agents

3

An example of an alkylating agent is:

cisplatin

4

T or F: A patient taking cisplatin will liekly experience mucositis and esophagitis.

FALSE

5

Patients taking this drug commonly experience severe nausea and vomiting, as well as a metallic aftertaste in their mouths

cisplatin

6

Antitumor antibiotics mechanism of action is:

inhibiting cell division by binding to DNA and interfering with RNA transcription

7

An example of an antitumor antibiotic is:

doxorubicin

8

A person taking doxorubicin is not likely to experience:

renal or hepatic toxicity

9

Patients that complain of an abnormal dryness of the mouth (xerostomia) are most likely taking:

doxurubicin

10

Drugs that interfere with nucleic acid synthesis by substituting drug for purines or pyrimidines necessary for normal cellular function are:

Antimetabolites

11

A patient taking an antimetabolite drug who is having difficulty with vitamin B12, fat and D-xylose absorption, has renal and hepatic toxicity, and change in taste acuity is taking:

methotrexate

12

When a patient is taking __________________ they should avoid pyridoxine supplementation

fluorouracil

13

A patient taking an antimetabolite drug and is experiencing moderate vomiting, anorexia, severe mucositis and esophagitis, diarrhea, and hepatic toxicity. Clinical tests reveal no sign of renal toxicity. The drug is:

fluorouracil

14

Hormones/hormone modifier drugs work by:

altering cellular metabolism by changing body hormonal milieu for unfavorable tumor growth

15

List one hormone used for treating cancer:

glucocorticoids

16

A person taking glucocorticoids may experience mild nausea and vomiting T or F:

TRUE

17

hyperpagia, sodium and fluid retention, gastrointestinal upset, glucose intolerance, K+ wasting, osteoporosis, and negative nitrogen balance are all sides effects of:

glucocorticoids

18

This class of cancer drug works by inhibiting mitotic spindle formation and blocking mitosis:

Plant alkaloids

19

Liat an example of a plant alkaloid drug:

vincristine

20

A person experiencing mild vomiting, anorexia, mucositis and esophagitis, alternating constipation and diarrhea, and hepatic toxicity is taking:

vincristine

21

What is one hallmark side effect of vincristine?

hyponatremia (abnormally low level of sodium in the blood)

22

Interferon is a biologic response modifier that works by:

modifying host biologic responses to tumor

23

A noticible weight change (increase or decrease)can be associated with which drug?

interferon

24

A person taking interferon is NOT likely to experience:

mucositis & esophagitis and renal toxicity

25

T or F: A patient taking interferon will most likely experience severe vomiting.

FALSE

26

Renal tubular necrosis is associated with taking:

cisplatin

27

Methotexate can have what effect on the liver?

It can cause hepatic fibrosis

28

Fluid retention is a common side effect for:

glucocorticoids

29

Both alkylating agents and antitumor antibiotics interfere with DNA and RNA transcription. What is the difference between the two?

alkylating agents work by substituting an alkyl group for a hydrogen atom which interfers with DNA replication, while antitumor antibiotics bind to DNA and inhibit cell division

30

A side effect of Cisplatin may be the decrease of which 3 minerals?

Serum magnesium, potassium, and zinc