Flashcards in Carbon Dioxide In The Blood Deck (15):
What are the content of CO2 in aterial blood?
What is the total content of O2 in aterial blood?
What happens to carbon dioxide in plasma?
Dissolved CO2 reacts with water to form carbonic acid, which quickly dissoicates to hydorgen ions and carbonate ions,
How do you determine thepH of the plasma?
Depends how much CO2 reacts to form and fhe concentration of hydorgen carbonate
What happens to plasma pH is the pCO2 rises?
The plasma pH will fall
What happens to the plasma pH is the PCO2 falls?
The plasma pH will rise
What is the plasma concentration of HCO3-?
25 mmol (mostly associated with Na+ not H+'
What is the enzyme is red blood cells use to drive the production of hydrogen carbonate?
What happens to the hydrogen carbonate produced?
H+ binds to the negatively cahrdged hydrogen carbonate and allows the reaction to proceed in the forward direction
What is the role of the kdiney in controlling HCO3- ?
It controls it by varying the excretion
What are the properties of haemoglobin are important for the buffering of CO2?
Buffering of H+ by hb depends on the level of oxygenation, if Hb is in the r state with more oxygen bound then less H+ ions bind, as at the lungs, but if there is less oxygen bound and the hameoglobin is in the t state more oxygen is bound, and is Hb bings more in cells than more HcO3- can be lroducedd
What happens ip venous blood with regards to CO2?
Hb has lost O2 and therefore binds more H+, allowing more HCO3- to form which is exported to the plasma, and this can cope with the extra dissolution of CO2
What happens when venous blood goes to the lungs?
Hb picks up the O2 and goes into the R state, and this causes Hb to give up the extra H+ it took on at the tissues, and the H+ reacts with HCO3- to for, CO2 which is breathed out
How do carboamino compunds form?
CP2 can bind directly to rpteins and the amine groups on the globin of ahv, and this binding of molecular CO2 contributes to Co2 transport and not the acid base balance