CARDIO - Lipid lowering agents Flashcards Preview

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Flashcards in CARDIO - Lipid lowering agents Deck (22):
1

Statins

[Lovastatin, Pravastatin, simvastatin, atorvastatin, rosuvastatin]

2

Statin MOA

[Lovastatin, Pravastatin, simvastatin, atorvastatin, rosuvastatin]

Blocks HMG-CoA Redutase (can't make mevalonate to make cholesterol)

3

Statin Lipid effects

Decrease LDL

Decrease TAG

Increase HDL

4

Statins AE

Hepatotoxicity

Myopathy (increase with fibrates and niacin)

5

Lipid lowering agent that decreases mortality in CAD patients

Statins

6

Fibrates:

Gemfibrozil, Clofibrate, bezafibrate, fenofibrate

7

Fibrates MOA

Activates PPAR-a (HDL synthesis)

Upregulates LPL

8

Fibrates lipid effects

Decrease LDL

Decrease TAG

Increase HDL

9

Fibrates toxicity

Myopathy (increase with statins)

Gallstones

10

Niacin MOA

Decrease FA release (by inhibiting HSL)

Decrease VLDL synthesis

Decrease HDL clearance 

11

Niacin lipid effects

Decrease LDL

Decrease TAG

Increase HDL

12

Niacin toxicity

Flushing and pruritis (stop with NSAIDs)

Hyperglycemia (acanthosis)

Hyperuricemia (gout)

Hepatotoxicity

13

Bile acid resins:

cholestyramine, cholestipol, cholesevelam

14

Bile acid resin MOA

Bind bile in intestines, prevent absorption in ileum

15

Bile acid resin lipid effects

Decrease LDL

Increase TAG

Increase HDL

16

bile acid resin toxicity

Nausea, bloating, cramps

Decreased absorption of other drugs and fat-soluble vitamins

17

Ezetemibe MOA

Prevent cholesterol absorption in small intestine

18

Ezetimibe lipid effects

Deceased LDL

19

Ezetimibe toxicity

Diarrhea

Hepatotoxicity with statins

20

Omega-3-FA MOA

Decrease TAG synthesis

21

Omega-3-FA lipid effects

Decrease TAG

22

Omega-3-FA toxicity

Nausea